Evidence map›Paper›PMID 37679603›Full record

ArticleProstate cancer and prostatic diseases2024

Relative search popularity of five advanced prostate cancer medications using Google Trends.

Sanjay Das, Nadine A Friedrich, James Daniels, G Cecilia Galvan, Jun Gong, Edwin Posadas, William Aronson, Stephen J Freedland

Open access · greenAbstract read
In one paragraph

Article in Prostate cancer and prostatic diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sanjay DasDepartment of Urology, University of California - Los Angeles, Los Angeles, CA, USA. sanjay.das@cshs.org.ORCID 0000-0001-8520-5280
Nadine A FriedrichDepartment of Urology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-6713-0614
James DanielsDepartment of Urology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-2401-2474
G Cecilia GalvanDepartment of Urology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-5892-3340
Jun GongSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-8713-1406
Edwin PosadasSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-8649-1346
William AronsonDepartment of Urology, University of California - Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-2107-5362
Stephen J FreedlandDepartment of Urology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-8104-6419
Cedars-Sinai Medical Center · USWest Los Angeles College · US

Funding

Training CoreTL1DK132768 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2021 to 2026
$3.4M
Network CoreU2CDK129496 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ISIDRO B. SALUSKY · 2021 to 2026
$2.9M
Patient-Centered Outcomes Research Training in Urologic and Gynecologic Cancers (PCORT UroGynCan)T32CA251072 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Beth Y. Karlan, MARK S. LITWIN · 2020 to 2026
$2.1M
A multidisciplinary training program in prostate cancerT32CA240172 · NCI · CEDARS-SINAI MEDICAL CENTER · PI BHOWMICK, NEIL A., FREEDLAND, STEPHEN JAY · 2019 to 2023
$988k
American Cancer Society (American Cancer Society, Inc.) RSG-18-018-01-CPHPSNCI NIH HHS T32 CA240172NCI NIH HHS T32 CA251072NIDDK NIH HHS TL1 DK132768NIDDK NIH HHS U2C DK129496U.S. Department of Defense (United States Department of Defense) W81XWH-19-1-0748U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32CA240172U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32CA251072U.S. Department of Health & Human Services | National Institutes of Health (NIH) U2C DK 129496
6 · The paper itself

Abstract

backgroundThere are many FDA-approved drugs for advanced prostate cancer (PC), yet public interest in these drugs is not well understood. We compared public interest and state-level predictors of interest in five common oral adjunctive hormonal therapies.

methodsGoogle Trends™ was queried for: "Enzalutamide", "Abiraterone Acetate", "Bicalutamide", "Apalutamide", and "Darolutamide" in the United States from January 2004 to November 2022. Data are presented as relative search index (RSI) by month. RSI ranges from 0 to 100 with 100 being peak popularity, 50 being half of the peak popularity, and 0 representing insufficient data to be determined.

resultsSeveral drugs abruptly increased in popularity following FDA approval including abiraterone, enzalutamide, and apalutamide. All drugs decreased in popularity from January 2020 to July 2020, corresponding with the COVID-19 pandemic. In the most recent 5 years, enzalutamide and abiraterone were the most common searched drugs, with bicalutamide a close 3

conclusionsDespite the emergence of more effective medications, bicalutamide remains relatively popular, particularly in states with lower household income, more uninsured adults, or those that did not expand Medicaid, possibly due to its lower cost.

Indexed as

Prostatic NeoplasmsAnilidesAntineoplastic AgentsBenzamidesHumansMaleNitrilesPhenylthiohydantoinSearch EngineThiohydantoinsUnited StatesAnilidesAntineoplastic AgentsBenzamidesenzalutamideNitrilesPhenylthiohydantoinThiohydantoins

Identifiers

PMID37679603
PMCPMC11019934
OpenAlexW4386513816

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.