ArticleNature structural & molecular biology2023
Substrate binding and inhibition of the anion exchanger 1 transporter.
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Article in Nature structural & molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Structural insights enable drug discovery for the neuronal NBCn2 carbonate transporter.Nature communications · 2026Article
- Transport mechanism of the SLC4 proteins-Lessons from recent structural and computational studies.The Journal of biological chemistry · 2026Review
- Stereospecificity Membrane Impact of Two Catechins on Red Blood Cells.Antioxidants (Basel, Switzerland) · 2026Article
- N-Glycosylation of Band 3 is essential for the binding of Ganoderma lucidum immunomodulatory protein rLZ-8.Applied microbiology and biotechnology · 2026Article
- Impact of anionic lipids on the energy landscape of conformational transition in anion exchanger 1 (AE1).Nature communications · 2025Article
- Spatiotemporal Control of the Formation of Luminescent Lanthanide Complexes in Liposome-Based Nanoreactors.Angewandte Chemie (International ed. in English) · 2025Article
- The SLC-ome of membrane transport: From molecular discovery to physiology and clinical applications.Physiological reviews · 2025Review
- Biophysical characterization and ion transport with cell-based and proteoliposome reconstitution assays of invertebrate KFEBS open bio · 2025Article
- Advances on the genetic basis of red cell membrane disorders.Current opinion in hematology · 2025Review
- Inactivation mechanisms of NaCommunications biology · 2025Article
- Role of channels in the ObioRxiv : the preprint server for biology · 2025Article
- Article
- The structural insight into the functional modulation of human anion exchanger 3.Nature communications · 2024Article
- Molecular dynamics simulations of lipid-protein interactions in SLC4 proteins.Biophysical journal · 2024Article
- Borate Transporters and SLC4 Bicarbonate Transporters Share Key Functional Properties.Membranes · 2023Article
- CryoEM structures of anion exchanger 1 capture multiple states of inward- and outward-facing conformations.Communications biology · 2022Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Michael J Capper *Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-0102-6993
Shifan Yang *Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-7616-1976
Alexander C Stone *Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-6830-7282
Sezen VatanseverDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gregory ZilbergDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yamuna Kalyani MathiharanDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Raul HabibDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Keino HutchinsonDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yihan ZhaoDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Avner SchlessingerDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-4007-7814
Mihaly MezeiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-0294-4307
Roman OsmanDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bin ZhangDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniel WackerDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. daniel.wacker@mssm.edu.ORCID http://orcid.org/0000-0003-4951-7230
Icahn School of Medicine at Mount Sinai · US
Funding
NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9MIntegrative Network Biology Approaches to Identify, Characterize and Validate Molecular Subtypes in Alzheimer's DiseaseU01AG046170 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WANG, MINGHUI, ZHANG, BIN · 2013 to 2022
$26.0MTRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7MTeaching biomedical and pharmacological trainees to produce FAIR data for AI & ML applicationsT32GM062754 · NIGMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHLESSINGER, AVNER · 2001 to 2023
$6.2MMapping Autoimmune Diabetes and Thyroiditis GenesR01DK067555 · NIDDK · UNIVERSITY OF CINCINNATI · PI MIHAELA STEFAN LIFSHITZ, YARON TOMER · 2005 to 2026
$5.8MThyroid Derived Peptide Presentation by HLA-DR in ThyroiditisR01DK073681 · NIDDK · UNIVERSITY OF CINCINNATI · PI TOMER, YARON · 2006 to 2022
$5.0MNovel Network Biology Approaches to Reposition FDA-approved Drugs for Alzheimer's DiseaseR01AG068030 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BRENNAND, KRISTEN JENNIFER, CAI, DONGMING · 2020 to 2024
$4.2MIdentifying Genes Linked to Autoimmune Thyroid DiseasesR01DK061659 · NIDDK · UNIVERSITY OF CINCINNATI · PI TOMER, YARON · 2002 to 2017
$4.1MTowards a comprehensive signaling pathway map of parahippocampal vulnerability in Alzheimers DiseaseRF1AG057440 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAROUTUNIAN, VAHRAM, NOGGLE, SCOTT ALLEN · 2017 to 2017
$3.5MStructural Studies and Drug Discovery Illuminate Serotonin PharmacologyR35GM133504 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Daniel Wacker · 2019 to 2026
$3.4MTraining Program in Substance Use DisordersT32DA053558 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Paul J. Kenny · 2021 to 2026
$2.6MSubstrate Specificity Determinants in Nutrient Solute Carrier TransportersR01CA277794 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Avner Schlessinger · 2023 to 2026
$1.7MNCI NIH HHS R01 CA277794NIA NIH HHS R01 AG068030NIA NIH HHS RF1 AG057440NIA NIH HHS U01 AG046170NIDA NIH HHS T32 DA053558NIDDK NIH HHS R01 DK061659NIDDK NIH HHS R01 DK067555NIDDK NIH HHS R01 DK073681NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R35 GM133504NIGMS NIH HHS T32 GM062754NIGMS NIH HHS U24 GM129539NIH HHS S10 OD019994
Abstract
Anion exchanger 1 (AE1), a member of the solute carrier (SLC) family, is the primary bicarbonate transporter in erythrocytes, regulating pH levels and CO
Indexed as
Anion Exchange Protein 1, ErythrocyteBicarbonatesBinding SitesMembrane Transport ProteinsProtein DomainsAnion Exchange Protein 1, ErythrocyteBicarbonatesMembrane Transport Proteins
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