ArticleNature immunology2023
CXCR6 orchestrates brain CD8
Open access · greenAbstract read
In one paragraph
Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 1 pooled it
24.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
138 citing papers in PubMed, 1 synthesis or guideline pooled it, 164 citations in OpenAlex.
- Bibliometric and visual analysis of single-cell multiomics in neurodegenerative disease arrest studies.Frontiers in neurology · 2024Pooled it
- Low-dose interleukin-2 in patients with mild to moderate Alzheimer's disease: a randomized clinical trial.Alzheimer's research & therapy · 2025Trial
- Targeting innovative therapeutic approaches to the hallmarks of aging to combat Alzheimer's disease.Neural regeneration research · 2026Article
- Chemokine levels in the murine brain from early postnatal development to aging.Brain, behavior, & immunity - health · 2026Article
- Targeting glial PD-1/PD-L1 restores microglial homeostasis and reduces neuronal hyperactivity in an Alzheimer's disease model.Science advances · 2026Article
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- Review
- N 6 -methyladenosine modification regulates cell death in cognitive impairment.Neural regeneration research · 2026Article
- Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection.Basic & clinical pharmacology & toxicology · 2026Review
- Neurodegenerative diseases and immune system: From pathogenic mechanism to therapy.Neural regeneration research · 2026Article
- Gamma-type immunoglobulin enhances phagocytosis of amyloid-beta fibrils by microglia.Neural regeneration research · 2026Article
- Neuroinflammation in Alzheimer's and Parkinson's diseases: pathogenic mechanisms and therapeutic strategies.Translational neurodegeneration · 2026Review
- Recent advances in Alzheimer's disease: From molecular mechanisms to therapeutic strategies.Cell · 2026Review
- Review
- Adaptive immunity in the pathogenesis of neurodegeneration.Nature immunology · 2026Review
- Targeting inflammaging in Alzheimer's disease: molecular pathways and emerging pharmacotherapies.Inflammopharmacology · 2026Review
- Human iPSC-derived neurons stimulated with IFNγ present HLA class I-restricted antigens to cytotoxic CD8Journal of neuroinflammation · 2026Article
- The Immune-Chemokine Axis in Alzheimer's Disease: Roles of Adaptive Immune System in Neuroinflammation and Disease Progression.Biomolecules · 2026Review
- Microglial ITAM & ITIM Signaling in Neurodegenerative Disease and Brain Aging.Journal of molecular biology · 2026Review
- Aged circulating CD8Immunity · 2026Article
78 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byCD82023
Authors and funding
27 authors at 3 institutions in 1 country.
Wei Su *Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-4165-8776
Jordy Saravia *Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-2691-501X
Isabel RischDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-3356-0349
Sherri RankinDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Cliff GuyDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Nicole M ChapmanDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hao ShiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-2796-629X
Yu SunDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Anil KcDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Wei LiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hongling HuangDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Seon Ah LimDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-6560-4874
Haoran HuDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yan WangDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Danting LiuDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yun JiaoDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ping-Chung ChenDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hadeer SolimanDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Koon-Kiu YanDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jonathan ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Peter VogelDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-7535-0545
Xueyan LiuDepartment of Mathematics, University of New Orleans, New Orleans, LA, USA.
Geidy E SerranoBanner Sun Health Research Institute, Sun City, AZ, USA.
Thomas G BeachBanner Sun Health Research Institute, Sun City, AZ, USA.
Jiyang YuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-3629-4330
Junmin PengDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-0472-7648
Hongbo ChiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA. hongbo.chi@stjude.org.ORCID 0000-0002-9997-2496
St. Jude Children's Research Hospital · USBanner Sun Health Research Institute · USUniversity of New Orleans · US
Funding
Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5MResearch Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI ALIREZA ATRI · 2021 to 2026
$24.9MNational Brain and Tissue Resource for Parkinson's Disease and Related DisordersU24NS072026 · NINDS · BANNER SUN HEALTH RESEARCH INSTITUTE · PI BEACH, THOMAS G · 2011 to 2015
$7.8MDissecting neuron-microglia-astrocyte interaction in AD pathogenesisRF1AG068581 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN, ROSSOLL, WILFRIED · 2020 to 2023
$5.4MRegulation of TH17 plasticity and stemness by mTORC1R01AI131703 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2018 to 2026
$4.1MDissecting neuron-microglia-astrocyte interaction in AD pathogenesisR01AG068581 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN, ROSSOLL, WILFRIED · 2024 to 2024
$1.2MNIAID NIH HHS R01 AI131703NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG072980NIA NIH HHS R01 AG068581NIA NIH HHS RF1 AG068581NINDS NIH HHS U24 NS072026
Abstract
Neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by innate immune-mediated inflammation, but functional and mechanistic effects of the adaptive immune system remain unclear. Here we identify brain-resident CD8
Indexed as
Alzheimer DiseaseCD8-Positive T-LymphocytesReceptors, CXCR6AnimalsBrainHumansMiceMicrogliaProgrammed Cell Death 1 ReceptorCXCR6 protein, humanCxcr6 protein, mouseProgrammed Cell Death 1 ReceptorReceptors, CXCR6
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.