Evidence map›Paper›PMID 37679422›Full record

ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2024

The stability of Staphylococcal bacteriophage in presence of local vancomycin concentrations used in clinical practice.

James B Doub, Guangchao Yu, Aaron Johnson, Yuzhu Mao, Birthe V Kjellerup

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Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

James B DoubThe Doub Translational Bacterial Research Laboratory, Division of Infectious Diseases, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD, 21201, USA. Jdoub@ihv.umaryland.edu.ORCID http://orcid.org/0000-0002-4977-0968
Guangchao YuClinical Laboratory Center, The First Affiliated Hospital of Jinan University, Guangzhou, People's Republic of China.
Aaron JohnsonDepartment of Orthopedic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Yuzhu MaoThe Kjellerup Biofilm Laboratory, Department of Civil and Environmental Engineering, University of Maryland, College Park, MD, USA.
Birthe V KjellerupThe Kjellerup Biofilm Laboratory, Department of Civil and Environmental Engineering, University of Maryland, College Park, MD, USA.
University of Maryland, Baltimore · USUniversity of Maryland, College Park · USFirst Affiliated Hospital of Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the stability of a clinically used Staphylococcal bacteriophage with doses of vancomycin that are encountered with local administration of vancomycin for musculoskeletal infections.

methodsA Staphylococcal bacteriophage was evaluated for stability in different pH ranges. Then that same bacteriophage was evaluated for stability with different concentrations of vancomycin and with vancomycin biodegradable antibiotic beads.

resultsThe bacteriophage had stability within a pH range of 4-10. There was a statistically significant (P < 0.05) decrease in the amount of bacteriophage over 24 h for vancomycin concentrations of 10 mg/mL and 100 mg/mL compared to lower vancomycin concentrations (1 mg/mL, 0.1 mg/mL and normal saline). However, no statistically significant decrease in the amount of bacteriophage was seen with biodegradable vancomycin beads over 24 h.

conclusionThese findings have important clinical ramifications in that they show local administration of bacteriophages with concomitant local vancomycin powder therapy should be avoided. Moreover, these findings should spearhead further research into bacteriophage stability in in vivo environments.

Indexed as

Staphylococcal InfectionsVancomycinAnti-Bacterial AgentsHumansStaphylococcus PhagesAnti-Bacterial AgentsVancomycinAntibiotic beadsBacteriophageMusculoskeletal infectionsProsthetic joint infectionsVancomycin

Identifiers

PMID37679422
OpenAlexW4386498927

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.