Evidence map›Paper›PMID 37679415›Full record

ArticleScientific reports2023

Development and in-vivo validation of a portable phosphorescence lifetime-based fiber-optic oxygen sensor.

Lilian Witthauer, Emmanuel Roussakis, Juan Pedro Cascales, Avery Goss, Xiaolei Li, Alexis Cralley, Dor Yoeli, Hunter B Moore, Zhaohui Wang, Yong Wang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Lilian WitthauerWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Emmanuel RoussakisWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Juan Pedro CascalesWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Avery GossWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Xiaolei LiWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Alexis CralleyDepartment of Surgery, University of Colorado Denver/Anschutz Medical Campus, Aurora, CO, USA.
Dor YoeliDepartment of Surgery, University of Colorado Denver/Anschutz Medical Campus, Aurora, CO, USA.
Hunter B MooreDepartment of Surgery, University of Colorado Denver/Anschutz Medical Campus, Aurora, CO, USA.
Zhaohui WangDepartment of Surgery, University of Colorado Denver/Anschutz Medical Campus, Aurora, CO, USA.
Yong WangDepartment of Surgery, University of Colorado Denver/Anschutz Medical Campus, Aurora, CO, USA.
Bing LiDepartment of Surgery, University of Colorado Denver/Anschutz Medical Campus, Aurora, CO, USA.
Christene A HuangDepartment of Surgery, University of Colorado Denver/Anschutz Medical Campus, Aurora, CO, USA.
Ernest E MooreDepartment of Surgery, University of Colorado Denver/Anschutz Medical Campus, Aurora, CO, USA.
Conor L EvansWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA. evans.conor@mgh.harvard.edu.
University of Colorado Anschutz Medical Campus · USHarvard University · USMassachusetts General Hospital · USUniversity of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxygenation is a crucial indicator of tissue viability and function. Oxygen tension ([Formula: see text]), i.e. the amount of molecular oxygen present in the tissue is a direct result of supply (perfusion) and consumption. Thus, measurement of [Formula: see text] is an effective method to monitor tissue viability. However, tissue oximetry sensors commonly used in clinical practice instead rely on measuring oxygen saturation ([Formula: see text]), largely due to the lack of reliable, affordable [Formula: see text] sensing solutions. To address this issue we present a proof-of-concept design and validation of a low-cost, lifetime-based oxygen sensing fiber. The sensor consists of readily-available off-the shelf components such as a microcontroller, a light-emitting diode (LED), an avalanche photodiode (APD), a temperature sensor, as well as a bright in-house developed porphyrin molecule. The device was calibrated using a benchtop setup and evaluated in three in vivo animal models. Our findings show that the new device design in combination with the bright porphyrin has the potential to be a useful and accurate tool for measuring [Formula: see text] in tissue, while also highlighting some of the limitations and challenges of oxygen measurements in this context.

Indexed as

Fiber Optic TechnologyPorphyrinsAnimalsBlood Gas AnalysisOximetryOxygenOxygenPorphyrins

Identifiers

PMID37679415
PMCPMC10484954
OpenAlexW4386494305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.