SynthesisJournal of vascular surgery2024
The mid-term effect of intravascular ultrasound on endovascular interventions for lower extremity peripheral arterial disease: A systematic review and meta-analysis.
Synthesis in Journal of vascular surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Should Interventional Radiologists Incorporate Intravascular Ultrasound (IVUS) Into Their Daily Practice? A Systematic Review and Meta-Analysis of IVUS in Peripheral Arterial Endovascular Interventions.Cardiovascular and interventional radiology · 2026Pooled it
- Comparative Effectiveness of Intravascular Ultrasound Versus Angiography in Abdominal and Thoracic Endovascular Aortic Repair: Systematic Review and Meta-Analysis.The American journal of cardiology · 2024Pooled it
- Twenty-Four-Month Outcomes of Intravascular Ultrasound-Guided Drug-Coated Balloon Angioplasty for Femoropopliteal Artery Disease.Journal of the American Heart Association · 2025Trial
- Optical Coherence Tomography and Its Potential Utility in Below-the-Knee Intervention: Can "Seeing More" Outweigh Practical Technology Limitations?Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- A Prospective Evaluation of Optical Coherence Tomography in Below-the-Knee Endovascular Interventions.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Popliteal cystic adventitial disease unmasked by intravascular ultrasound.Journal of vascular surgery cases and innovative techniques · 2026Article
- Cost-effectiveness of intravascular ultrasound (IVUS) vs. angiography-guided revascularization in femoropopliteal occlusive disease.Cost effectiveness and resource allocation : C/E · 2026Article
- Intravascular imaging in peripheral arterial disease: a contemporary literature review.European heart journal open · 2026Review
- Effectiveness of balloon angioplasty under intravascular ultrasound guidance in calcified below-the-knee tibial arteries.Diagnostic and interventional radiology (Ankara, Turkey) · 2025Article
- Construction and validation of a nomogram model for predicting the risk of recurrence in patients with lower extremity arteriosclerosis obliterans after surgical intervention.Journal of cardiothoracic surgery · 2025Article
- Appropriateness of Care Measures: A Novel Approach to Quality.Annals of vascular surgery · 2024Article
- Drug-coated balloon versus drug-eluting stent for femoropopliteal total occlusions: intraluminal versus subintimal approaches.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
11 authors at 10 institutions in 2 countries.
Funding
Abstract
objectiveIntravascular ultrasound (IVUS) is an important adjunctive tool for patients with lower extremity peripheral arterial disease (PAD) undergoing endovascular therapy (EVT). The evidence regarding the advantages of IVUS use is evolving, and recent studies have reported conflicting results. We aimed to perform a meta-analysis to evaluate the efficacy of IVUS during angiography-guided EVT for patients with PAD.
methodsMEDLINE and EMBASE were searched through April 2023 to identify studies that investigated the outcomes of IVUS with angiography-guided EVT vs angiography-alone-guided EVT. The primary outcome was restenosis/occlusion rate; secondary outcomes were target lesion revascularization, major amputation, and mortality.
resultsOne randomized controlled trial and 14 observational studies, largely of moderate quality, were included, yielding a total of 708,808 patients with 709,189 lesions that were treated with IVUS-guided EVT (n = 101,405) vs angiography-alone (n = 607,784). Compared with angiography alone, IVUS-guided EVT was associated with a non-significant trend towards decreased restenosis/occlusion (relative risk [RR], 0.74; 95% confidence interval [CI], 0.54-1.00; I
conclusionsIVUS-guided EVT for PAD may possibly be associated with a lower major amputation rate compared with angiography alone-guided EVT, although the difference in patency remained an insignificant trend in favor of IVUS-guided EVT. Adjunctive use of IVUS during EVT may be beneficial, and further prospective studies are warranted to delineate this relationship and the applicability of this technology in routine practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.