Evidence map›Paper›PMID 37678605›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2024

To decline or not to decline: Consequences of decision-making regarding lung offers from donors with hepatitis C.

Jessica M Ruck, Mary G Bowring, Christine M Durand, Jinny S Ha, Allan B Massie, Dorry L Segev, Christian A Merlo, Errol L Bush

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of thoracic and cardiovascular surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jessica M RuckDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Mary G BowringDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Christine M DurandDivision of Infectious Disease, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md.
Jinny S HaDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Allan B MassieDepartment of Surgery, New York University Grossman School of Medicine and Langone Health, New York, NY; Department of Population Health, New York University Grossman School of Medicine and Langone Health, New York, NY.
Dorry L SegevDepartment of Surgery, New York University Grossman School of Medicine and Langone Health, New York, NY; Department of Population Health, New York University Grossman School of Medicine and Langone Health, New York, NY; Scientific Registry of Transplant Recipients, Minneapolis, Minn.
Christian A MerloDivision of Pulmonology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md.
Errol L BushDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md. Electronic address: errol.bush@jhu.edu.
Johns Hopkins University · USNYU Langone Health · US

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Continuous allocation score design for guaranteeing equity and reducing discards in kidney and liver transplantationR01DK132395 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Allan B Massie · 2023 to 2026
$2.7M
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Frailty and post-liver transplant delirium and cognitive impairment in older recipientsF32AG067642 · NIA · JOHNS HOPKINS UNIVERSITY · PI RUCK, JESSICA MOORE · 2021 to 2023
$258k
Leveraging a novel health records platform to predict the development of cardiovascular disease following kidney transplantationF30HL168842 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BOWRING, MARY GRACE · 2023 to 2025
$170k
NHLBI NIH HHS F30 HL168842NIAID NIH HHS K24 AI144954NIA NIH HHS F32 AG067642NIDDK NIH HHS K24 DK101828NIDDK NIH HHS R01 DK132395NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

objectiveLung transplants from donors with hepatitis C (HCV D+) have excellent outcomes, but these organs continue to be declined. We evaluated whether (1) being listed to consider and (2) accepting versus declining HCV D+ offers provided a survival benefit to lung transplant candidates.

methodsUsing the Scientific Registry of Transplant Recipients, we identified all adult (≥18 years) lung transplant candidates 2016-2021 and compared waitlist mortality between those willing versus not willing to consider HCV D+ offers using competing risk regression. We identified all candidates offered an HCV D+ lung that was later accepted and followed them from offer decision until death or end-of-study. We estimated adjusted mortality risk of accepting versus declining an HCV D+ lung offer using propensity-weighted Cox regression.

resultsFrom 2016 to 2021, we identified 21,007 lung transplant candidates, 33.8% of whom were willing to consider HCV D+ offers. Candidates willing to consider HCV D+ offers had a 17% lower risk of waitlist mortality (subhazard ratio, 0.83; 95% confidence interval, 0.75-0.91, P < .001). Over the same period, 665 HCV D+ lung offers were accepted after being declined a total of 2562 times. HCV D+ offer acceptance versus decline was associated with a 20% lower risk of mortality (adjusted hazard ratio, 0.80; 95% confidence interval, 0.66-0.96, P = .02).

conclusionsConsidering HCV D+ lung offers was associated with a 17% lower risk of waitlist mortality, whereas accepting versus declining an HCV D+ lung offer was associated with a 20% lower risk of mortality. Centers and candidates should consider accepting suitable HCV D+ lung offers to optimize outcomes.

Indexed as

Hepatitis CLung TransplantationTissue DonorsWaiting ListsAdultAgedDonor SelectionFemaleHumansMaleMiddle AgedRegistriesRisk AssessmentRisk FactorsTime FactorsTissue and Organ Procurementhepatitis Clung offerslung transplantmortalitywaitlist

Identifiers

PMID37678605
PMCPMC10924072
OpenAlexW4386529834

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.