Evidence map›Paper›PMID 37678551›Full record

ArticleJournal of thrombosis and haemostasis : JTH2023

PACSIN2 regulates platelet integrin β1 hemostatic function.

Ratnashree Biswas, Emily K Boyd, Nathan Eaton, Agata Steenackers, Marie L Schulte, Friedrich Reusswig, Hongyin Yu, Caleb Drew, Walter H A Kahr, Qizhen Shi and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Ratnashree BiswasVersiti Blood Research Institute, Milwaukee, Wisconsin, USA; Translational Glycomics Center, Milwaukee, Wisconsin, USA.
Emily K BoydVersiti Blood Research Institute, Milwaukee, Wisconsin, USA; Translational Glycomics Center, Milwaukee, Wisconsin, USA; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Nathan EatonVersiti Blood Research Institute, Milwaukee, Wisconsin, USA; Translational Glycomics Center, Milwaukee, Wisconsin, USA; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Agata SteenackersVersiti Blood Research Institute, Milwaukee, Wisconsin, USA; Translational Glycomics Center, Milwaukee, Wisconsin, USA.
Marie L SchulteVersiti Blood Research Institute, Milwaukee, Wisconsin, USA.
Friedrich ReusswigVersiti Blood Research Institute, Milwaukee, Wisconsin, USA; Translational Glycomics Center, Milwaukee, Wisconsin, USA.
Hongyin YuVersiti Blood Research Institute, Milwaukee, Wisconsin, USA; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Caleb DrewVersiti Blood Research Institute, Milwaukee, Wisconsin, USA; Translational Glycomics Center, Milwaukee, Wisconsin, USA.
Walter H A KahrProgram in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada; Departments of Paediatrics and Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Qizhen ShiVersiti Blood Research Institute, Milwaukee, Wisconsin, USA; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Children's Research Institute, Children's Wisconsin, Milwaukee, Wisconsin, USA.
Markus PlomannCenter for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany.
Karin M HoffmeisterVersiti Blood Research Institute, Milwaukee, Wisconsin, USA; Translational Glycomics Center, Milwaukee, Wisconsin, USA; Departments of Biochemistry and Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Hervé FaletVersiti Blood Research Institute, Milwaukee, Wisconsin, USA; Translational Glycomics Center, Milwaukee, Wisconsin, USA; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address: hfalet@versiti.org.
Medical College of Wisconsin · USVersiti Blood Center of Wisconsin · USChildren's Hospital of Wisconsin · USUniversity of Cologne · DEUniversity of Toronto · CA

Funding

Project 3: Role of Glycosaminoglycans in HematopoiesisP01HL151333 · NHLBI · VERSITI WISCONSIN, INC. · PI WEILER, HARTMUT KARL-HEINZ · 2021 to 2025
$12.3M
Carbohydrate-Mediated Platelet ClearanceR01HL089224 · NHLBI · VERSITI WISCONSIN, INC. · PI Karin Maria Hoffmeister · 2007 to 2026
$9.3M
Platelet-Derived FVIII Gene Therapy of Hemophilia AR01HL102035 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Qizhen Shi · 2010 to 2026
$7.0M
Glycans in Blood Homeostasis and DiseaseK12HL141954 · NHLBI · VERSITI WISCONSIN, INC. · PI DAHMS, NANCY M., DESAI, UMESH RAMANLAL · 2018 to 2022
$4.9M
Endocytosis in platelet and megakaryocyte biologyR01HL126743 · NHLBI · VERSITI WISCONSIN, INC. · PI FALET, HERVE · 2016 to 2019
$1.7M
NHLBI NIH HHS K12 HL141954NHLBI NIH HHS P01 HL151333NHLBI NIH HHS R01 HL089224NHLBI NIH HHS R01 HL102035NHLBI NIH HHS R01 HL126743
6 · The paper itself

Abstract

backgroundUpon vessel injury, platelets adhere to exposed matrix constituents via specific membrane receptors, including the von Willebrand factor receptor glycoprotein (GP)Ib-IX-V complex and integrins β1 and β3. In platelets, the Fes/CIP4-homology Bin-Amphiphysin-Rvs protein PACSIN2 associates with the cytoskeletal and scaffolding protein filamin A (FlnA), linking GPIbα and integrins to the cytoskeleton.

objectivesHere we investigated the role of PACSIN2 in platelet function.

methodsPlatelet parameters were evaluated in mice lacking PACSIN2 and platelet integrin β1.

resultsPacsin2

conclusionsPacsin2

Indexed as

Integrin beta1Platelet ActivationThrombosisAdaptor Proteins, Signal TransducingAnimalsBlood PlateletsHemostasisHemostaticsMicePeptidesPlatelet AdhesivenessPlatelet Glycoprotein GPIIb-IIIa ComplexPlatelet Membrane GlycoproteinsReceptors, CollagenAdaptor Proteins, Signal TransducingHemostaticsIntegrin beta1Pacsin2 protein, mousePeptidesPlatelet Glycoprotein GPIIb-IIIa ComplexPlatelet Membrane GlycoproteinsReceptors, Collagenbleedingfilamin Aintegrin β1PACSIN2platelets

Identifiers

PMID37678551
PMCPMC10841284
OpenAlexW4386530804

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.