Evidence map›Paper›PMID 37677000›Full record

Trial reportJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics2023

Efficacy and Safety of the Melanocortin Pan-Agonist PL9643 in a Phase 2 Study of Patients with Dry Eye Disease.

David Evans, Kenneth Kenyon, George Ousler, Michael Watson, Patrick Vollmer, Eugene B McLaurin, Gail Torkildsen, Jason Winters, John Dodd, Robert Jordan and 2 more

Abstract readRandomized Controlled TrialClinical Trial, Phase II
In one paragraph

Trial report in Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Quintessence of currently approved and upcoming treatments for dry eye disease.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

David EvansTotal Eye Care, Memphis, Tennessee, USA.
Kenneth KenyonTufts University School of Medicine and New England Eye Center, Boston, Massachusetts, USA.
George OuslerOra, Inc., Andover, Massachusetts, USA.
Michael WatsonOra, Inc., Andover, Massachusetts, USA.
Patrick VollmerVita Eye Clinic, Shelby, North Carolina, USA.
Eugene B McLaurinTotal Eye Care, Memphis, Tennessee, USA.
Gail TorkildsenAndover Eye Associates, Andover, Massachusetts, USA.
Jason WintersPalatin Technologies, Inc., Cranbury, New Jersey, USA.
John DoddPalatin Technologies, Inc., Cranbury, New Jersey, USA.
Robert JordanPalatin Technologies, Inc., Cranbury, New Jersey, USA.
Stephen T WillsPalatin Technologies, Inc., Cranbury, New Jersey, USA.
Carl SpanaPalatin Technologies, Inc., Cranbury, New Jersey, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Dry Eye SyndromesCorneaDouble-Blind MethodFluoresceinHumansOphthalmic SolutionsTearsTreatment OutcomeFluoresceinOphthalmic Solutionsconjunctival stainingdry eye diseaseefficacymelanocortin receptor agonistPL9643tear film breakup time

Identifiers

PMID37677000
PMCPMC10654643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.