ArticlemSphere2023
The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS.
Open access · goldAbstract read
In one paragraph
Article in mSphere, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 6 citations in OpenAlex.
- Transcriptome Profiling ofAntibiotics (Basel, Switzerland) · 2026Article
- Antimicrobial peptide resistance in Salmonella AMR: the role of surface binding and lipopolysaccharide remodelling: one health implications.World journal of microbiology & biotechnology · 2026Review
- ESBL-ProducingMicroorganisms · 2025Article
- Article
- YgiV promoter mutations cause resistance to cystobactamids and reduced virulence factor expression in Escherichia coli.npj antimicrobials and resistance · 2024Article
- Breaking Barriers: Exploiting Envelope Biogenesis and Stress Responses to Develop Novel Antimicrobial Strategies in Gram-Negative Bacteria.Pathogens (Basel, Switzerland) · 2024Review
- Metabolic flux regulates growth transitions and antibiotic tolerance in uropathogenicJournal of bacteriology · 2024Article
Corrections and comments
- Update of
Authors and funding
10 authors at 4 institutions in 1 country.
Melanie N HurstDivision of Molecular Pathogenesis, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center , Nashville, Tennessee, USA.
Connor J BeeboutDivision of Molecular Pathogenesis, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center , Nashville, Tennessee, USA.
Alexis HollingsworthDepartment of Biological Sciences, Vanderbilt University , Nashville, Tennessee, USA.
Kirsten R GuckesDivision of Molecular Pathogenesis, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center , Nashville, Tennessee, USA.
Alexandria PurcellDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA.
Tomas A BermudezDivision of Molecular Pathogenesis, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center , Nashville, Tennessee, USA.
Diamond WilliamsDepartment of Biological Sciences, Vanderbilt University , Nashville, Tennessee, USA.
Seth A ReasonerDivision of Molecular Pathogenesis, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center , Nashville, Tennessee, USA.
M Stephen TrentDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA.ORCID 0000-0001-6134-1800
Maria HadjifrangiskouDivision of Molecular Pathogenesis, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center , Nashville, Tennessee, USA.ORCID 0000-0003-4249-8997
Vanderbilt University Medical Center · USUniversity of Georgia · USVanderbilt University · USVanderbilt Health · US
Funding
pan-Genome of E.coli in the bladder and gut of women with recurrent UTIP50DK064540 · NIDDK · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2002 to 2017
$17.9MPATHOGENIC FIBER FORMATION IN BACTERIA: STRUCTURAL BASISR01AI048689 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2001 to 2020
$7.6MThe Cell Envelope of the Multi-Drug Resistant Pathogen Acinetobacter baumanniiR01AI150098 · NIAID · UNIVERSITY OF GEORGIA · PI Michael Stephen Trent · 2020 to 2026
$3.9MDevelopment of a novel vaccine platform: Surface Antigen/Adjuvant Vaccine Engineering (SAAVE)R01AI129940 · NIAID · UNIVERSITY OF GEORGIA · PI TRENT, MICHAEL STEPHEN · 2017 to 2021
$3.3MThe role of cardiolipin in the biogenesis of the Gram-negative bacterial cell envelopeR01AI174416 · NIAID · UNIVERSITY OF GEORGIA · PI Michael Stephen Trent · 2023 to 2026
$2.4MMolecular mechanisms required for the maintenance of the gram-negative outer membraneR01AI138576 · NIAID · UNIVERSITY OF GEORGIA · PI TRENT, MICHAEL STEPHEN · 2018 to 2022
$2.0MTwo-component system interactions as uropathogenic Escherichia coli drug targetsR01AI107052 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HADJIFRANGISKOU, MARIA · 2015 to 2019
$1.9MThe Vanderbilt Urologic Infection Repository, a Resource for Personalized Clinical DiscoveryP20DK123967 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HADJIFRANGISKOU, MARIA · 2019 to 2020
$680kThe role of cytochrome bd in uropathogenic Escherichia coli pathogenesisF30AI150077 · NIAID · VANDERBILT UNIVERSITY · PI BEEBOUT, CONNOR JAMES · 2020 to 2022
$125kElucidating the mechanisms of transient polymyxin resistance in pathogenic E. coli.F31AI143244 · NIAID · VANDERBILT UNIVERSITY · PI HURST, MELANIE N · 2019 to 2021
$85kDefining a Molecular Signature of Uropathogenic Escherichia coliF31DK131902 · NIDDK · VANDERBILT UNIVERSITY · PI MORALES, GRACE · 2022 to 2023
$65kNIAID NIH HHS F30 AI150077NIAID NIH HHS F31 AI143244NIAID NIH HHS R01 AI048689NIAID NIH HHS R01 AI107052NIAID NIH HHS R01 AI129940NIAID NIH HHS R01 AI138576NIAID NIH HHS R01 AI150098NIAID NIH HHS R01 AI174416NIDDK NIH HHS F31 DK131902NIDDK NIH HHS P20 DK123967NIDDK NIH HHS P50 DK064540
Abstract
The modification of lipopolysaccharide (LPS) in
Indexed as
Anti-Bacterial AgentsEscherichia coli ProteinsBacterial ProteinsEscherichia coliGlutamatesKetoglutaric AcidsLipid ALipopolysaccharidesPolymyxin BTranscription FactorsAnti-Bacterial AgentsBacterial ProteinsEscherichia coli ProteinsGlutamatesKetoglutaric AcidsLipid ALipopolysaccharidesPolymyxin BQseB protein, E coliTranscription Factorsamino acid metabolismantibioticsQseBtoleranceUPEC
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.