Evidence map›Paper›PMID 37676766›Full record

ArticleCell reports2023

Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes.

Olga Mielczarek, Carolyn H Rogers, Yinxiu Zhan, Louise S Matheson, Michael J T Stubbington, Stefan Schoenfelder, Daniel J Bolland, Biola M Javierre, Steven W Wingett, Csilla Várnai and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 3 countries.

Olga MielczarekNuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Carolyn H RogersNuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK; Immunology Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Yinxiu ZhanFriedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
Louise S MathesonNuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK; Immunology Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Michael J T StubbingtonNuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Stefan SchoenfelderNuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Daniel J BollandNuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK; Immunology Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Biola M JavierreNuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Steven W WingettBioinformatics Group, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Csilla VárnaiNuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Anne Segonds-PichonBioinformatics Group, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Simon J ConnFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Felix KruegerBioinformatics Group, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Simon AndrewsBioinformatics Group, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Peter FraserNuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Luca GiorgettiFriedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
Anne E CorcoranNuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK; Immunology Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK. Electronic address: anne.corcoran@babraham.ac.uk.
Babraham Institute · GBFriedrich Miescher Institute · CHFlinders University · AU

Funding

Medical Research Council MR/T016787/1
6 · The paper itself

Abstract

To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (V

Indexed as

B-LymphocytesImmunoglobulinsGenes, Immunoglobulin Heavy ChainPrecursor Cells, B-LymphoidV(D)J RecombinationImmunoglobulins3D immunoglobulin structureCapture Hi-CCP: Immunologygenome organizationimmunoglobin locusinterchromosomalpolymer modeling

Identifiers

PMID37676766
PMCPMC10548092
OpenAlexW4386478924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.