ArticleStress biology2023
Effects of perinatal stress on the metabolites and lipids in plasma of dairy goats.
Article in Stress biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Rabbit Does as a Model for Studying Plasma Metabolomic Adaptations Across Reproductive Stages: Insights from Parturition to Weaning.Veterinary sciences · 2026Article
- Longitudinal clinical-chemical profiles and metabolic dynamics in Thuringian Forest dairy goats during pregnancy and lactation under organic farming conditions.Veterinary world · 2026Article
- Early-Onset Negative Energy Balance in Transition Dairy Cows Increases the Incidence of Retained Fetal Membranes.Animals : an open access journal from MDPI · 2026Article
- Effects of chokeberry pomace supplementation on biochemical, metabolic and antioxidant parameters in high-yielding dairy goats.Journal of veterinary research · 2025Article
- Glucose Metabolism-Modifying Natural Materials for Potential Feed Additive Development.Pharmaceutics · 2024Review
- Comparative metabolomics reveals serum metabolites changes in goats during different developmental stages.Scientific reports · 2024Article
- Effect of strontium on transcription factors identified by transcriptome analyses of bovine ruminal epithelial cells.BMC veterinary research · 2024Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Dairy goats experience metabolic stress during the peripartal period, and their ability to navigate this stage of lactation is related to the occurrence and development of metabolic diseases. Unlike dairy cows, there is a lack of comprehensive analysis of changes in the plasma profiles of peripartal dairy goats, particularly using high-throughput techniques. A subset of 9 clinically-healthy dairy goats were used from a cohort of 96 primiparous Guanzhong dairy goats (BCS, 2.75 ± 0.15). Blood samples were collected at seven time points around parturition (d 21, 14, 7 before parturition, the day of kidding, and d 7, 14, 21 postpartum), were analyzed using untargeted metabolomics and targeted lipidomics. The orthogonal partial least squares discriminant analysis model revealed a total of 31 differential metabolites including p-cresol sulfate, pyruvic acid, cholic acid, and oxoglutaric acid. The pathway enrichment analysis identified phenylalanine metabolism, aminoacyl-tRNA biosynthesis, and citrate cycle as the top three significantly-altered pathways. The Limma package identified a total of 123 differentially expressed lipids. Phosphatidylserine (PS), free fatty acids (FFA), and acylcarnitines (ACs) were significantly increased on the day of kidding, while diacylglycerols (DAG) and triacylglycerols (TAG) decreased. Ceramides (Cer) and lyso-phosphatidylinositols (LPI) were significantly increased during postpartum period, while PS, FFA, and ACs decreased postpartum and gradually returned to antepartum levels. Individual species of FFA and phosphatidylcholines (PC) were segregated based on the differences in the saturation and length of the carbon chain. Overall, this work generated the largest repository of the plasma lipidome and metabolome in dairy goats across the peripartal period, which contributed to our understanding of the multifaceted adaptations of transition dairy goats.
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Registered trials
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