ArticleSocial cognitive and affective neuroscience2023
Emotion regulation of social pain: double dissociation of lateral prefrontal cortices supporting reappraisal and distraction.
Article in Social cognitive and affective neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 14 citations in OpenAlex.
- Inflammation, fronto-amygdala connectivity, and negative affective reactivity to daily stress in adolescents.Brain, behavior, & immunity - health · 2026Article
- Disrupted brain functional networks in adolescents and young adults with gaming disorder during social interaction: An fNIRS study.Psychological medicine · 2026Article
- Resilience through regulation: Individual differences in inhibitory control shape neural and psychological responses to ostracism.Cognitive, affective & behavioral neuroscience · 2026Article
- Decision-making experience for second donation in unrelated hematopoietic stem cell donors: a descriptive qualitative study.Journal of cancer survivorship : research and practice · 2025Article
- Interpersonal brain synchronization in social pain contexts: an fNIRS-based exploration of empathy.Social cognitive and affective neuroscience · 2025Article
- Scarcity mindset facilitates empathy for social pain and prosocial intention: behavioral and neural evidences.Social cognitive and affective neuroscience · 2025Article
- Mediation and Interaction of Cognitive Reappraisal in the Relationship Between Depression and Social Pain Among College Students.Psychology research and behavior management · 2025Article
- Survival, Attachment, and Healing: An Evolutionary Lens on Interventions for Trauma-Related Dissociation.Psychology research and behavior management · 2024Review
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) are both crucial regions involved in voluntary emotion regulation. However, it remains unclear whether the two regions show functional specificity for reappraisal and distraction. This study employed transcranial magnetic stimulation (TMS) to explore, in a real social interactive scenario, whether different lateral prefrontal regions play relatively specific roles in downregulating social pain via reappraisal and distraction. Participants initially took part in a social interactive game, followed by receiving either active (the DLPFC- or VLPFC-activated group, n = 100 per group) or control (the vertex-activated group, n = 100) TMS session. They were then instructed to use both distraction and reappraisal strategies to downregulate any negative emotions evoked by the social evaluation given by their peers who interacted with them previously. Results demonstrated that the TMS-activated DLPFC has a greater beneficial effect during distraction, whereas the activated VLPFC has a greater beneficial effect during reappraisal. This result investigated the direct experience of social pain and extended previous findings on empathy-related responses to affective pictures while also controlling for confounding factors such as empathic concern. Therefore, we are now confident in the double dissociation proposal of the DLPFC and VLPFC in distraction and reappraisal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.