ArticleThe journal of physical chemistry letters2023
Simulating the Voltage-Dependent Fluorescence of Di-8-ANEPPS in a Lipid Membrane.
Article in The journal of physical chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- The Many Layers of Membrane Biophysics: Environment-Sensitive Fluorophores Report on Structural Organization of Biological Membranes at Various Depths.Analytical chemistry · 2026Article
- Disorder in Order-Related Membrane Biophysical Parameters: An In-Depth Analysis of Di-4-ANEPPDHQ Generalized Polarization.The journal of physical chemistry letters · 2026Article
- Fluorescent Labeling Methods for Brain Structure Research.Molecules (Basel, Switzerland) · 2026Review
- Milk-Derived EVs from Different Animal Sources: An Overview on Their Detection, Isolation and Pleiotropic Exerted Effects.International journal of molecular sciences · 2026Review
- Resistive-Pulse Sensing Coupled with Fluorescence Lifetime Imaging Microscopy for Differentiation of Individual Liposomes.ACS nano · 2025Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Voltage-sensitive fluorescent dyes such as di-8-ANEPPS (di-8-aminonaphthylethylenepyridinium propylsulfonate) are powerful tools to study biological membranes. Its fluorescence is affected by changes in the membrane potential and other factors, requiring extensive calibration to extract meaningful quantitative results. The amphiphilic di-8-ANEPPS molecule is expected to bind at the membrane-solution interface. However, atomic-level information is sparse about its position and orientation in the membrane, especially in regards to how the latter dynamically fluctuates to affect the observed fluorescence. In the present work, molecular dynamics simulations of the ground and excited states of di-8-ANEPPS embedded in a DPPC membrane as represented by classical force fields were used to investigate how the fluorescence is affected by externally applied potential. The calculations reproduce the shifts in the wavelength of emission as a function of voltage that are observed experimentally, indicating that the approach can help better understand the various factors that can affect the fluorescence of membrane-bound dyes.
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Registered trials
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