SynthesisInternational journal of stroke : official journal of the International Stroke Society2023
Systematic review: Pharmacological interventions for the treatment of post-stroke fatigue.
Synthesis in International journal of stroke : official journal of the International Stroke Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- ESTREL-Fatigue-association of levodopa with post-stroke fatigue.European stroke journal · 2026Trial
- The role of nutritional supplement on post-stroke fatigue: a pilot randomized controlled trial.The journal of nutrition, health & aging · 2024Trial
- A double-blind randomized control trial of transcranial direct current stimulation in post-stroke fatigue.Frontiers in neurologyTrial
- The Impact of Tilburg Frailty on Poststroke Fatigue in First-Ever Stroke Patients: A Cross-Sectional Study With Unified Measurement Tools and Improved Statistics.Annals of clinical and translational neurology · 2026Article
- Narrative Review on Post-Stroke Outcomes Through Recognition of Frailty, Sarcopenia, and Palliative Care Needs.Healthcare (Basel, Switzerland) · 2025Review
- Post-stroke hemiplegic limb cold sensation and sympathetic nervous regulation: A review.The Journal of international medical research · 2025Review
- A technology-enriched approach to increasing rehabilitation dose after stroke: Clinical feasibility study.Clinical rehabilitation · 2025Article
- Sleep-Disordered Breathing Shortly After Stroke Is Not Associated With Poststroke Fatigue at 3 Months.Neurology open access · 2025Article
- Prevalence of Fatigue and Associations With Depression and Cognitive Impairment in Patients With CADASIL.Neurology · 2025Article
- Behavioral and Neural correlates of Post-STROKE Fatigue: A randomized controlled trial protocol.PloS one · 2025Article
- Are central and systemic inflammation associated with fatigue in cerebral small vessel disease?International journal of stroke : official journal of the International Stroke Society · 2024Article
- Post-stroke fatigue interventions for stroke survivors: A scoping review.Belitung nursing journal · 2024Article
- Post-Stroke Fatigue in Patients at 3 Months After Ischemic Stroke: Analysis From the FRAILTY Study.SAGE open nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-stroke fatigue (PSF) affects around 50% of stroke survivors. Previous systematic reviews of randomized controlled trials found insufficient evidence to guide practice, but most excluded Chinese studies. Furthermore, their searches are now out-of-date.
aimsTo systematically review and perform a meta-analysis of randomized placebo-controlled trials of pharmacological interventions for treating PSF.
methodsWe screened Airitri, CNKI, VIP, CINAHL, ClinicalTrials.gov, CENTRAL, Cochrane Stroke Group Trial Register, EMBASE, EU Clinical Trial Register, ISRCTN, MEDLINE, PsycINFO, Wanfang, and WHO ICTRP up to 11 November 2022. Our primary outcome was fatigue severity. We conducted subgroup analysis by drug type and sensitivity analysis after excluding the trials at high risk of bias. Secondary outcomes included mood and quality of life.
resultsWe screened 33,297 citations and identified 10 published completed trials, 6 unpublished completed trials, and 6 ongoing trials. Pharmacological treatments were associated with lower fatigue severity at the end of treatment (10 published completed trials, 600 participants, pooled standardized mean difference (SMD) = -0.80, 95% confidence interval (CI): -1.29 to -0.31; I
conclusionThere is insufficient evidence to support a particular pharmacological treatment for PSF, thus current clinical guidelines do not require amendment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.