Evidence map›Paper›PMID 37675986›Full record

ArticleeLife2023

Translation of dipeptide repeat proteins in

Yoshifumi Sonobe, Soojin Lee, Gopinath Krishnan, Yuanzheng Gu, Deborah Y Kwon, Fen-Biao Gao, Raymond P Roos, Paschalis Kratsios

Abstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yoshifumi SonobeUniversity of Chicago Medical Center, Chicago, United States.
Soojin LeeRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, United States.
Gopinath KrishnanRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, United States.
Yuanzheng GuNeuromuscular & Movement Disorders, Biogen, Cambridge, United States.
Deborah Y KwonNeuromuscular & Movement Disorders, Biogen, Cambridge, United States.
Fen-Biao GaoRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, United States.
Raymond P Roos *University of Chicago Medical Center, Chicago, United States.
Paschalis Kratsios *Neuroscience Institute, University of Chicago, Chicago, United States.ORCID 0000-0002-1363-9271

Funding

Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1R37NS057553 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2018 to 2024
$4.3M
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsR01NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Fen-Biao Gao · 2017 to 2026
$3.6M
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsRF1NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2022 to 2022
$2.1M
NINDS NIH HHS R01 NS101986NINDS NIH HHS R37 NS057553NINDS NIH HHS RF1 NS101986
6 · The paper itself

Abstract

A hexanucleotide repeat expansion in

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinFrontotemporal DementiaPick Disease of the BrainCodon, InitiatorDipeptidesHumansProteinsC9orf72 ProteinC9orf72 protein, humanCodon, InitiatorDipeptidesProteinsamyotrophic lateral sclerosisAUG initiation codonsC9ORF72dipeptide protein repeatsfrontotemporal dementiageneticsgenomicshumaniPSC-derived neuronsmouseneuroscience

Identifiers

PMID37675986
PMCPMC10541178

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.