Evidence map›Paper›PMID 37675838›Full record

ArticleEndocrine connections2023

Trabecular bone density in middle-aged women with reproductive disorders.

Charissa van Zwol-Janssens, Aglaia Hage, Kim van der Ham, Birgitta K Velthuis, Ricardo P J Budde, Maria P H Koster, Arie Franx, Bart C J M Fauser, Eric Boersma, Daniel Bos and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine connections, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Charissa van Zwol-JanssensC van Zwol - Janssens, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, Netherlands.ORCID 0000-0001-8966-2948
Aglaia HageA Hage, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, Netherlands.ORCID 0000-0003-3401-4585
Kim van der HamK van der Ham, Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, Netherlands.
Birgitta K VelthuisB Velthuis, Department of Radiology, UMC Utrecht, Utrecht, Netherlands.
Ricardo P J BuddeR Budde, Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands.
Maria P H KosterM Koster, Department of Obstetrics and Gynecology, Erasmus MC, Rotterdam, Netherlands.
Arie FranxA Franx, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, Netherlands.
Bart C J M FauserB Fauser, Department of Reproductive Medicine and Gynecology, UMC Utrecht, Utrecht, Netherlands.
Eric BoersmaE Boersma, Cardiology, Erasmus MC, Rotterdam, Netherlands.
Daniel BosD Bos, Department of Radiology and Nuclear Medicine and Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands.
Joop S E LavenJ Laven, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, Netherlands.
Yvonne V LouwersY Louwers, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, Netherlands.
the CREW consortium
Erasmus MC · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Besides age, estrogen exposure plays a crucial role in changes in bone density (BD) in women. Premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS) are conditions in reproductive-aged women in which the exposure to estrogen is substantially different. Women with a history of preeclampsia (PE) are expected to have normal estrogen exposure. Within the CREw-IMAGO study, we investigated if trabecular BD is different in these women because of differences in the duration of estrogen exposure. Trabecular BD was measured in thoracic vertebrae on coronary CT scans. Women with an reduced estrogen exposure (POI) have a lower BD compared to women with an intermediate exposure (PE) (mean difference (MD) -26.8, 95% confidence interval (CI) -37.2 - -16.3). Women with a prolonged estrogen exposure (PCOS) have the highest BD (MD 15.0, 95% CI 4.3 - 25.7). These results support the hypothesis that the duration of estrogen exposure in these women is associated with trabecular BD.

Identifiers

PMID37675838
PMCPMC10563647
OpenAlexW4386505053

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.