Evidence map›Paper›PMID 37675828›Full record

ArticleJournal of the International AIDS Society2023

Sexual and drug use risk behaviour trajectories among people treated for recent HCV infection: the REACT study.

Joanne M Carson, Sebastiano Barbieri, Evan Cunningham, Eric Mao, Marc van der Valk, Jürgen K Rockstroh, Margaret Hellard, Arthur Kim, Sanjay Bhagani, Jordan J Feld and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International AIDS Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Trajectories of Chemsex Engagement Across Time Among PrEP-Using Men Who Have Sex with Men: Results from the French ANRS-Prévenir Cohort.International journal of sexual health : official journal of the World Association for Sexual Health · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Joanne M CarsonKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Sebastiano BarbieriThe Centre for Big Data Research in Health, UNSW Sydney, Sydney, New South Wales, Australia.
Evan CunninghamKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Eric MaoKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Marc van der ValkDivision of Infectious Diseases, Amsterdam Infection and Immunity Institute, University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Jürgen K RockstrohUniversity Hospital Bonn, Bonn, Germany.
Margaret HellardBurnet Institute, Melbourne, Victoria, Australia.ORCID 0000-0002-5055-3266
Arthur KimMassachusetts General Hospital, Boston, Massachusetts, USA.
Sanjay BhaganiRoyal Free Hospital, London, UK.
Jordan J FeldToronto Centre for Liver Diseases, Toronto General Hospital, Toronto, Ontario, Canada.
Ed GaneAuckland City Hospital, Auckland, New Zealand.
Maria C ThurnheerDepartment of Infectious Diseases, Bern Inselspital, Bern, Switzerland.
Julie BruneauResearch Center, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Elise TuKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Gregory J DoreKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Gail V MatthewsKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Marianne MartinelloKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
REACT study groupKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.

Funding

NIH HHS
6 · The paper itself

Abstract

introductionExploration of sexual and drug use behaviours following treatment for recent hepatitis C virus (HCV) is limited. This analysis modelled behavioural trajectories following treatment for recent HCV and assessed reinfection.

methodsParticipants treated for recent HCV in an international trial (enrolled 2017-2019) were followed at 3-monthly intervals for up to 2 years to assess longitudinal behaviours. Population-averaged changes were assessed using generalized estimating equations. Distinct behavioural trajectories were identified using group-based trajectory modelling. HCV reinfection incidence was calculated using person-years (PY) of observation.

resultsDuring the follow-up of 212 participants (84% gay and bisexual men [GBM]; 69% HIV; 26% current injecting drug use [IDU]), behavioural trajectories for IDU and stimulant use (past month) did not change. However, population-averaged decreases in the likelihood of daily IDU (adjusted odds ratio [AOR] 0.83; 95% CI 0.72, 0.95) and opioid use (AOR 0.84; 95% CI 0.75, 0.93) were observed. Among GBM, behavioural trajectories for chemsex did not change. Population-averaged decreases in condomless anal intercourse with casual male partners (CAI-CMP) (AOR 0.95; 95% CI 0.90, 0.99) and group-sex (AOR 0.86; 95% CI 0.80, 0.93) were observed, but masked distinct trajectories. While a proportion had a decreased probability of CAI-CMP (23%) and group-sex (59%) post-treatment, a substantial proportion retained a high probability of these behaviours. High HCV reinfection incidence was observed for the sustained high probability IDU (33.0/100 PY; 95% CI 17.7, 61.3) and chemsex (23.3/100 PY; 95% CI 14.5, 37.5) trajectories.

conclusionsLimited sexual and drug use behavioural change was observed following treatment for recent HCV, supporting access to surveillance and (re)treatment.

Indexed as

Hepatitis CHIV InfectionsOpioid-Related DisordersHepacivirusHumansMaleReinfectionRisk-TakingGBMHCVHIVPWIDreinfectionSTI

Identifiers

PMID37675828
PMCPMC10483502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.