Evidence map›Paper›PMID 37675796›Full record

ArticleJournal of medical virology2023

Ethno-demographic disparities in humoral responses to the COVID-19 vaccine among healthcare workers.

Pankaj Ahluwalia, Ashutosh Vashisht, Harmanpreet Singh, Nikhil Shri Sahajpal, Ashis K Mondal, Kimya Jones, Jaspreet Farmaha, Ryan Bloomquist, Caroline Marie Carlock, Drew Fransoso and 14 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 1 country.

Pankaj AhluwaliaDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Ashutosh VashishtDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Harmanpreet SinghDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Nikhil Shri SahajpalGreenwood Genetic Centre, Greenwood, South Carolina, USA.
Ashis K MondalDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Kimya JonesDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Jaspreet FarmahaDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Ryan BloomquistDental College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID 0000-0003-3514-8593
Caroline Marie CarlockDental College of Georgia, Augusta University, Augusta, Georgia, USA.
Drew FransosoDental College of Georgia, Augusta University, Augusta, Georgia, USA.
Christina SunDental College of Georgia, Augusta University, Augusta, Georgia, USA.
Tyler DayDental College of Georgia, Augusta University, Augusta, Georgia, USA.
Comfort PrahDental College of Georgia, Augusta University, Augusta, Georgia, USA.
Trinh VuongDental College of Georgia, Augusta University, Augusta, Georgia, USA.
Patty RayClinical Trials Office, Augusta University, Augusta, Georgia, USA.
Danielle BradshawGeorgia Cancer Center at Augusta University, Augusta, Georgia, USA.
Marisol Miranda GalvisGeorgia Cancer Center at Augusta University, Augusta, Georgia, USA.
Sadanand FulzeleDepartment of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Girindra RavalGeorgia Cancer Center at Augusta University, Augusta, Georgia, USA.
Justin Xavier MooreGeorgia Cancer Center at Augusta University, Augusta, Georgia, USA.
Jorge CortesGeorgia Cancer Center at Augusta University, Augusta, Georgia, USA.
Jeffrey N JamesDental College of Georgia, Augusta University, Augusta, Georgia, USA.
Vamsi KotaGeorgia Cancer Center at Augusta University, Augusta, Georgia, USA.
Ravindra KolheDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Augusta University · USAugusta University Health · USGreenwood Genetic Center · US

Funding

COVID Supplement - COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES,75N93019C00052 · NIAID · UNIVERSITY OF GEORGIA · PI ROSS, TED · 2019 to 2025
$74.6M
NIAID NIH HHS 75N93019C00052
6 · The paper itself

Abstract

The COVID-19 pandemic had a profound impact on global health, but rapid vaccine administration resulted in a significant decline in morbidity and mortality rates worldwide. In this study, we sought to explore the temporal changes in the humoral immune response against SARS-CoV-2 healthcare workers (HCWs) in Augusta, GA, USA, and investigate any potential associations with ethno-demographic features. Specifically, we aimed to compare the naturally infected individuals with naïve individuals to understand the immune response dynamics after SARS-CoV-2 vaccination. A total of 290 HCWs were included and assessed prospectively in this study. COVID status was determined using a saliva-based COVID assay. Neutralizing antibody (NAb) levels were quantified using a chemiluminescent immunoassay system, and IgG levels were measured using an enzyme-linked immunosorbent assay method. We examined the changes in antibody levels among participants using different statistical tests including logistic regression and multiple correspondence analysis. Our findings revealed a significant decline in NAb and IgG levels at 8-12 months postvaccination. Furthermore, a multivariable analysis indicated that this decline was more pronounced in White HCWs (odds ratio [OR] = 2.1, 95% confidence interval [CI] = 1.07-4.08, p = 0.02) and IgG (OR = 2.07, 95% CI = 1.04-4.11, p = 0.03) among the whole cohort. Booster doses significantly increased IgG and NAb levels, while a decline in antibody levels was observed in participants without booster doses at 12 months postvaccination. Our results highlight the importance of understanding the dynamics of immune response and the potential influence of demographic factors on waning immunity to SARS-CoV-2. In addition, our findings emphasize the value of booster doses to ensure durable immunity.

Indexed as

COVID-19COVID-19 VaccinesAntibodies, NeutralizingHealth PersonnelHumansImmunoglobulin GPandemicsSARS-CoV-2Antibodies, NeutralizingCOVID-19 VaccinesImmunoglobulin GantibodiesboosterCOVID-19ethnicityneutralizing antibodypandemicracial disparitySARS-CoV-2vaccinevirus

Identifiers

PMID37675796
PMCPMC10536788
OpenAlexW4386508948

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.