Evidence map›Paper›PMID 37675632›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2023

Oxidized Phospholipid oxPAPC Alters Regulatory T-Cell Differentiation and Decreases Their Protective Function in Atherosclerosis in Mice.

Brenna D Appleton, Sydney A Palmer, Harrison P Smith, Lilly E Stephens, Amy S Major

Open access · greenAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. LCN2-Driven Fibroblast Ferroptosis-Associated Injury Promotes Keratinocyte Proliferation via Lipid Peroxidation Signaling in Psoriasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Review
  4. Structural and molecular principles of DAMP biology.Nature structural & molecular biology · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Brenna D AppletonDepartment of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN (B.D.A., A.S.M.).ORCID 0000-0001-7939-4783
Sydney A PalmerDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (S.A.P., H.P.S., L.E.S., A.S.M.).ORCID 0009-0001-7585-1067
Harrison P SmithDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (S.A.P., H.P.S., L.E.S., A.S.M.).ORCID 0009-0004-7725-6810
Lilly E StephensDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (S.A.P., H.P.S., L.E.S., A.S.M.).ORCID 0009-0000-3749-9739
Amy S MajorDepartment of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN (B.D.A., A.S.M.).ORCID 0000-0003-0377-2041
Vanderbilt University Medical Center · USVanderbilt University · US

Funding

Interdisciplinary Training in Rheumatic DiseasesT32AR059039 · NIAMS · VANDERBILT UNIVERSITY · PI Tracy Minan Frech, AMY S MAJOR · 2010 to 2026
$4.3M
Targeting Tfh Cell Metabolic Regulation in SLE and SLE-Associated AtherosclerosisR01AI153167 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MAJOR, AMY S, RATHMELL, JEFFREY C. · 2020 to 2024
$2.8M
Investigating mechanisms of oxidized phospholipid-mediated dysregulation of regulatory T cells in atherosclerosisR21AI176219 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MAJOR, AMY S · 2023 to 2024
$481k
Oxidized Low-Density Lipoprotein Immune Complexes Stimulate Proinflammatory Changes in Innate and Adaptive ImmunityF31HL154569 · NHLBI · VANDERBILT UNIVERSITY · PI APPLETON, BRENNA · 2020 to 2022
$93k
oxLDL immune complex-mediated modulation of atherosclerosisI01BX002968 · VA · VETERANS HEALTH ADMINISTRATION · PI MAJOR, AMY S · 2016 to 2019
–
Fc Receptors in Atherosclerosis: Linking Innate and Adaptive Immunity.I01BX005333 · VA · VETERANS HEALTH ADMINISTRATION · PI MAJOR, AMY S · 2021 to 2024
–
BLRD VA I01 BX002968BLRD VA I01 BX005333NHLBI NIH HHS F31 HL154569NIAID NIH HHS R01 AI153167NIAID NIH HHS R21 AI176219NIAMS NIH HHS T32 AR059039
6 · The paper itself

Abstract

backgroundRegulatory T cells (T

methodsCD4

resultsCompared with controls, oxPAPC-treated T

conclusionsOxPAPC elicits T

Indexed as

AtherosclerosisPhospholipidsAnimalsCell DifferentiationInterferon-gammaMicePhosphatidylcholinesT-Lymphocytes, RegulatoryInterferon-gammaoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholinePhosphatidylcholinesPhospholipidsatherosclerosiscell deathdisease progressioninterferonphospholipid

Identifiers

PMID37675632
PMCPMC10720352
OpenAlexW4386504028

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.