Evidence map›Paper›PMID 37675611›Full record

ArticleStroke2023

Determinants and Temporal Trends of Dual Antiplatelet Therapy After Mild Noncardioembolic Stroke.

Victor J Del Brutto, Ruijie Yin, Hannah Gardener, Hao Ying, Carolina M Gutierrez, Angus M Jameson, David Z Rose, Ayham Alkhachroum, Dianne Foster, Chuanhui Dong and 7 more

Open access · greenAbstract read
In one paragraph

Article in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Victor J Del BruttoDepartment of Neurology, University of Miami Miller School of Medicine, FL (V.J.D.B., R.Y., H.G., H.Y., C.M.G., A.A., C.D., N.B.S., G.G.P., T.R., N.A., R.L.S., J.G.R.).ORCID 0000-0002-5115-6916
Ruijie YinDepartment of Neurology, University of Miami Miller School of Medicine, FL (V.J.D.B., R.Y., H.G., H.Y., C.M.G., A.A., C.D., N.B.S., G.G.P., T.R., N.A., R.L.S., J.G.R.).ORCID 0000-0001-6375-2929
Hannah GardenerDepartment of Neurology, University of Miami Miller School of Medicine, FL (V.J.D.B., R.Y., H.G., H.Y., C.M.G., A.A., C.D., N.B.S., G.G.P., T.R., N.A., R.L.S., J.G.R.).ORCID 0000-0003-1416-632X
Hao YingDepartment of Neurology, University of Miami Miller School of Medicine, FL (V.J.D.B., R.Y., H.G., H.Y., C.M.G., A.A., C.D., N.B.S., G.G.P., T.R., N.A., R.L.S., J.G.R.).
Carolina M GutierrezDepartment of Neurology, University of Miami Miller School of Medicine, FL (V.J.D.B., R.Y., H.G., H.Y., C.M.G., A.A., C.D., N.B.S., G.G.P., T.R., N.A., R.L.S., J.G.R.).ORCID 0000-0002-9879-3912
Angus M JamesonUniversity of South Florida Morsani College of Medicine, Tampa (A.M.J., D.Z.R.).ORCID 0000-0003-0944-8656
David Z RoseUniversity of South Florida Morsani College of Medicine, Tampa (A.M.J., D.Z.R.).ORCID 0000-0002-9449-6494
Ayham AlkhachroumDepartment of Neurology, University of Miami Miller School of Medicine, FL (V.J.D.B., R.Y., H.G., H.Y., C.M.G., A.A., C.D., N.B.S., G.G.P., T.R., N.A., R.L.S., J.G.R.).ORCID 0000-0003-0352-5913
Dianne FosterAmerican Heart Association, Southeast Marietta, GA (D.F.).ORCID 0009-0009-8972-9079
Chuanhui DongDepartment of Neurology, University of Miami Miller School of Medicine, FL (V.J.D.B., R.Y., H.G., H.Y., C.M.G., A.A., C.D., N.B.S., G.G.P., T.R., N.A., R.L.S., J.G.R.).ORCID 0000-0001-7165-355X
Selina AnchetaJackson Memorial Hospital, Miami, FL (S.A.).
Nicole B SurDepartment of Neurology, University of Miami Miller School of Medicine, FL (V.J.D.B., R.Y., H.G., H.Y., C.M.G., A.A., C.D., N.B.S., G.G.P., T.R., N.A., R.L.S., J.G.R.).ORCID 0000-0002-3541-3599
Gillian Gordon PerueDepartment of Neurology, University of Miami Miller School of Medicine, FL (V.J.D.B., R.Y., H.G., H.Y., C.M.G., A.A., C.D., N.B.S., G.G.P., T.R., N.A., R.L.S., J.G.R.).ORCID 0000-0002-3991-3179
Tatjana RundekDepartment of Neurology, University of Miami Miller School of Medicine, FL (V.J.D.B., R.Y., H.G., H.Y., C.M.G., A.A., C.D., N.B.S., G.G.P., T.R., N.A., R.L.S., J.G.R.).ORCID 0000-0002-7115-9815
Negar AsdaghiDepartment of Neurology, University of Miami Miller School of Medicine, FL (V.J.D.B., R.Y., H.G., H.Y., C.M.G., A.A., C.D., N.B.S., G.G.P., T.R., N.A., R.L.S., J.G.R.).ORCID 0000-0002-0285-825X
Ralph L SaccoDepartment of Neurology, University of Miami Miller School of Medicine, FL (V.J.D.B., R.Y., H.G., H.Y., C.M.G., A.A., C.D., N.B.S., G.G.P., T.R., N.A., R.L.S., J.G.R.).ORCID 0000-0003-4629-684X
Jose G RomanoDepartment of Neurology, University of Miami Miller School of Medicine, FL (V.J.D.B., R.Y., H.G., H.Y., C.M.G., A.A., C.D., N.B.S., G.G.P., T.R., N.A., R.L.S., J.G.R.).ORCID 0000-0003-3667-2792
University of Miami · USUnited States Nuclear Regulatory Commission · USUniversity of South Florida · USAmerican Heart Association · USJackson Memorial Hospital · US

Funding

Miami Clinical and Translational Science InstituteUL1TR002736 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, KOBETZ, ERIN N · 2018 to 2022
$23.2M
Miami Clinical and Translational Science InstituteUM1TR004556 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Olveen Carrasquillo, ERIN N KOBETZ · 2023 to 2026
$16.0M
The Data Management and BiostatisticsU54NS081763 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SACCO, RALPH L. · 2013 to 2017
$4.2M
Institutional Career Development CoreKL2TR002737 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RUNDEK, TATJANA, SCOTT, GWENDOLYN BARBARA · 2018 to 2022
$3.6M
Miami Clinical and Translational Science Institute K12 ProgramK12TR004555 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALESSIA FORNONI, Tatjana Rundek · 2023 to 2026
$3.0M
MUSICA - MUsic and Speech Induced Cerebral ActivationK23NS126577 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Ayham Alkhachroum · 2022 to 2026
$910k
COVERT– COvert Volitional Eye Response TestR21NS128326 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALKHACHROUM, AYHAM, CLAASSEN, JAN · 2022 to 2023
$428k
NCATS NIH HHS K12 TR004555NCATS NIH HHS KL2 TR002737NCATS NIH HHS UL1 TR002736NCATS NIH HHS UM1 TR004556NINDS NIH HHS K23 NS126577NINDS NIH HHS R21 NS128326NINDS NIH HHS U54 NS081763
6 · The paper itself

Abstract

backgroundShort-term dual antiplatelet therapy (DAPT) reduces early stroke recurrence after mild noncardioembolic ischemic stroke (NCIS). We aim to evaluate temporal trends and determinants of DAPT prescription after mild NCIS in the Florida Stroke Registry, a statewide registry across Get With The Guidelines-Stroke participating hospitals.

methodsIn this cross-sectional analysis of a cohort study, we included patients with mild NCIS (National Institutes of Health Stroke Scale score ≤3) who were potentially eligible for DAPT across 168 Florida Stroke Registry participating hospitals between January 2010 and September 2022. Using antiplatelet prescription as the dependent variable (DAPT versus single antiplatelet therapy), we fit logistic regression models adjusted for patient-related factors, hospital-related factors, clinical presentation, vascular risk factors, and ischemic stroke subtype, to obtain adjusted odds ratios (aORs) with 95% CIs.

resultsFrom 283 264 Florida Stroke Registry ischemic stroke patients during the study period, 109 655 NCIS were considered eligible. Among these, 37 058 patients with National Institutes of Health Stroke Scale score >3 were excluded, resulting in a sample of 72 597 mild NCIS (mean age 68±14 years; female 47.3%). Overall, 24 693 (34.0%) patients with mild NCIS were discharged on DAPT and 47 904 (66.0%) on single antiplatelet therapy. DAPT prescription increased from 25.7% in 2010 to 52.8% in 2022 (

conclusionsDespite a temporal trend increase in DAPT prescription after mild NCIS, we found substantial underutilization of evidence-based DAPT associated with significant disparities in stroke care.

Indexed as

Ischemic StrokeStrokeAgedAged, 80 and overAspirinClopidogrelCohort StudiesCross-Sectional StudiesDrug Therapy, CombinationFemaleHumansMiddle AgedPlatelet Aggregation InhibitorsTreatment OutcomeAspirinClopidogrelPlatelet Aggregation Inhibitorsaspirinatherosclerosisclopidogrelhyperlipidemiaischemic stroke

Identifiers

PMID37675611
PMCPMC10530464
OpenAlexW4386504012

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.