ArticleCirculation research2023
ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1.
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Article in Circulation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 45 citations in OpenAlex.
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- Dysregulated Sheddase Signalling as a Molecular Driver of Plaque Instability Revealed by Integrative Transcriptomics.Journal of cellular and molecular medicine · 2026Article
- ADAMTS7 promotes smooth muscle foam cell expansion in atherosclerosis.The Journal of clinical investigation · 2026Article
- A hierarchical theranostic nanoagent for multimodal imaging and targeted foam cell intervention in atherosclerosis.Nature communications · 2026Article
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- MiR-7683-3p from M2-exosomes attenuated atherosclerosis by activating the PPARγ-LXRα-ABCG1 pathway mediated cholesterol efflux of vascular smooth muscle cell derived foam cells.Journal of nanobiotechnology · 2025Article
- Epithelial sodium channel in dendritic cells participates in high-fat-induced inflammatory responses.Molecular biology reports · 2025Article
- An interplay of non-coding RNAs regulatesResearch square · 2025Article
- Genetic Risk Profiles for Atherosclerosis and Venous Thromboembolism in Azorean and Mainland Portuguese Populations: A Comparative Analysis.Current issues in molecular biology · 2025Article
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Authors and funding
24 authors at 6 institutions in 1 country.
M Amin SharifiDepartment of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).ORCID 0000-0003-3532-9271
Michael WiererDepartment of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany (M.W., M.M.).ORCID 0000-0002-0356-5571
Tan An DangDepartment of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).
Jelena MilicDivision of Vascular Biology, Institute for Stroke and Dementia Research, Ludwig Maximilian University of Munich, Germany (J.M., J.B.).
Aldo MoggioDepartment of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).ORCID 0000-0001-6513-5406
Nadja SachsVascular Biology and Experimental Vascular Medicine Unit, Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany (N.S., L.M.).ORCID 0000-0001-8031-017X
Moritz von ScheidtDepartment of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).ORCID 0000-0001-7159-8271
Julia HinterdoblerDepartment of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).
Philipp MüllerDepartment of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).ORCID 0000-0002-4850-0472
Julia WernerDepartment of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).ORCID 0000-0002-4374-5374
Barbara StillerDepartment of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).
Zouhair AherrahrouInstitute for Cardiogenetics and University Heart Centre Lübeck, University of Lübeck, Germany (Z.A., J.E.).ORCID 0000-0002-1241-8733
Jeanette ErdmannInstitute for Cardiogenetics and University Heart Centre Lübeck, University of Lübeck, Germany (Z.A., J.E.).ORCID 0000-0002-4486-6231
Andrea ZalianiFraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).ORCID 0000-0002-1740-8390
Mira GraettingerFraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).ORCID 0000-0002-5909-4828
Jeanette ReinshagenFraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).ORCID 0000-0002-8080-9170
Sheraz GulFraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).
Philip GribbonFraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).ORCID 0000-0001-7655-2459
Lars MaegdefesselGerman Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Germany (M.A.S., T.A.D., M.v.S., J.H., P.M., J.W., L.M., J.B., H.B.S., H.S., T.K.).ORCID 0000-0001-5228-2634
Jürgen BernhagenGerman Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Germany (M.A.S., T.A.D., M.v.S., J.H., P.M., J.W., L.M., J.B., H.B.S., H.S., T.K.).
Hendrik B SagerDepartment of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).ORCID 0000-0002-0197-6553
Matthias MannDepartment of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany (M.W., M.M.).ORCID 0000-0003-1292-4799
Heribert SchunkertDepartment of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).ORCID 0000-0001-6428-3001
Thorsten KesslerDepartment of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).ORCID 0000-0003-3326-1621
German Centre for Cardiovascular Research · DEFraunhofer Institute for Translational Medicine and Pharmacology · DEDeutsches Herzzentrum München · DEMax Planck Institute of Biochemistry · DETUM Klinikum · DELudwig-Maximilians-Universität München · DE
Funding
British Heart FoundationEuropean Research Council 101077205
Abstract
backgroundThe
methodsTargets of ADAMTS-7 were identified by high-resolution mass spectrometry of atherosclerotic plaques from Apoe
resultsIn humans,
conclusionsADAMTS-7, which is induced in unstable atherosclerotic plaques, decreases TIMP-1 stability reducing its inhibitory effect on MMP-9, which is known to promote collagen degradation and is likewise associated with coronary artery disease. Disrupting the interaction of ADAMTS-7 and TIMP-1 might be a strategy to increase collagen content and plaque stability for the reduction of atherosclerosis-related events.
Indexed as
ADAMTS7 ProteinAtherosclerosisCoronary Artery DiseasePlaque, AtheroscleroticTissue Inhibitor of Metalloproteinase-1AnimalsCollagenHumansMatrix Metalloproteinase 9MiceMice, Knockout, ApoEADAMTS7 ProteinADAMTS7 protein, humanAdamts7 protein, mouseCollagenMatrix Metalloproteinase 9Tissue Inhibitor of Metalloproteinase-1aortaatherosclerosisdisintegrinsmicesolubility
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