Evidence map›Paper›PMID 37675459›Full record

ArticleAmerican journal of physiology. Renal physiology2023

Intracellular signaling pathways of muscarinic acetylcholine receptor-mediated detrusor muscle contractions.

Helga Balla, Kinga Borsodi, Petra Őrsy, Béla Horváth, Péter József Molnár, Ádám Lénárt, Mónika Kosztelnik, Éva Ruisanchez, Jürgen Wess, Stefan Offermanns and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Helga BallaInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-0672-6860
Kinga BorsodiInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0003-0939-4416
Petra ŐrsyInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.
Béla HorváthInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.
Péter József MolnárInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-2508-2343
Ádám LénártInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-2962-818X
Mónika KosztelnikInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0001-6735-3597
Éva RuisanchezInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0001-7779-226X
Jürgen WessMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, United States.ORCID 0000-0003-0818-1232
Stefan OffermannsDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.ORCID 0000-0001-8676-6805
Péter NyirádyDepartment of Urology, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-7037-4919
Zoltán BenyóInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0001-6015-0359
Semmelweis University · HUMax Planck Institute for Heart and Lung Research · DENational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Gedeon Richter Plc Talent FoundationInnovációs és Technológiai Minisztérium (Ministry for Innovation and Technology) 2020-1.1.6-JÖVŐ-2021-00010Innovációs és Technológiai Minisztérium (Ministry for Innovation and Technology) TKP2021-EGA-25NKFI | National Research, Development and Innovation Office K-125174NKFI | National Research, Development and Innovation Office K-135683NKFI | National Research, Development and Innovation Office K-139230NKFI | National Research, Development and Innovation Office PD-132851Semmelweis Egyetem (Semmelweis University) EFOP-3.6.3-VEKOP-16-2017-00009
6 · The paper itself

Abstract

Acetylcholine plays an essential role in the regulation of detrusor muscle contractions, and antimuscarinics are widely used in the management of overactive bladder syndrome. However, several adverse effects limit their application and patients' compliance. Thus, this study aimed to further analyze the signal transduction of M

Indexed as

Muscle ContractionMuscle, SmoothReceptor, Muscarinic M2Receptor, Muscarinic M3Signal TransductionUrinary BladderAnimalsCarbacholGTP-Binding Protein alpha Subunits, Gq-G11MaleMiceMice, Inbred C57BLMice, KnockoutrhoA GTP-Binding Proteinrho-Associated KinasesCarbacholGTP-Binding Protein alpha Subunits, Gq-G11Receptor, Muscarinic M2Receptor, Muscarinic M3rhoA GTP-Binding ProteinRhoA protein, mouserho-Associated KinasesG proteinsmuscarinic receptorRhoAsignal transductionurinary bladder smooth muscle

Identifiers

PMID37675459
PMCPMC11905796
OpenAlexW4386505114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.