Evidence map›Paper›PMID 37675109›Full record

ArticleFrontiers in immunology2023

Alice Mac Donald, Delphine Guipouy, William Lemieux, Mario Harvey, Louis-Jean Bordeleau, David Guay, Hugo Roméro, Yuanyi Li, Renaud Dion, Kathie Béland and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Alice Mac DonaldCentre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Montréal, QC, Canada.
Delphine GuipouyCentre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Montréal, QC, Canada.
William LemieuxCentre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Montréal, QC, Canada.
Mario HarveyFeldan Therapeutics, Québec, QC, Canada.
Louis-Jean BordeleauFeldan Therapeutics, Québec, QC, Canada.
David GuayFeldan Therapeutics, Québec, QC, Canada.
Hugo RoméroCentre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Montréal, QC, Canada.
Yuanyi LiCentre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Montréal, QC, Canada.
Renaud DionCentre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Montréal, QC, Canada.
Kathie BélandCentre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Montréal, QC, Canada.
Elie HaddadCentre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Montréal, QC, Canada.
Centre Hospitalier Universitaire Sainte-Justine · CAFeldan (Canada) · CAUniversité de Montréal · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Natural Killer (NK) cells hold the potential to shift cell therapy from a complex autologous option to a universal off-the-shelf one. Although NK cells have demonstrated efficacy and safety in the treatment of leukemia, the limited efficacy of NK cell-based immunotherapies against solid tumors still represents a major hurdle. In the immunosuppressive tumor microenvironment (TME), inhibitory interactions between cancer and immune cells impair antitumoral immunity. Methods: To restore NK cell cytotoxicity against HLA-E Results: Conclusions: Our results demonstrate that

Indexed as

Killer Cells, NaturalLeukemiaAnimalsHLA-E AntigensHumansMiceProtein TransportReceptors, Natural Killer CellTumor MicroenvironmentHLA-E AntigensReceptors, Natural Killer CellcytotoxicityHLA-Einhibitory receptornatural killer cellsNKG2Asolid tumor

Identifiers

PMID37675109
PMCPMC10478211
OpenAlexW4386068166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.