Evidence map›Paper›PMID 37674984›Full record

ArticleiScience2023

Metabolic and functional remodeling of colonic macrophages in response to high-fat diet-induced obesity.

Angela Castoldi, David E Sanin, Nikki van Teijlingen Bakker, Cristhiane F Aguiar, Lauar de Brito Monteiro, Nisha Rana, Katarzyna M Grzes, Agnieszka M Kabat, Jonathan Curtis, Alanna M Cameron and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Defective efferocytosis in diabetes: molecular mechanisms and emerging therapeutic strategies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 3 countries.

Angela CastoldiDepartment of Immunology, University of Sao Paulo, Sao Paulo, Brazil.
David E SaninDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Nikki van Teijlingen BakkerDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Cristhiane F AguiarDepartment of Immunology, University of Sao Paulo, Sao Paulo, Brazil.
Lauar de Brito MonteiroDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Nisha RanaDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Katarzyna M GrzesDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Agnieszka M KabatDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Jonathan CurtisDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Alanna M CameronDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
George CaputaDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Tiago Antônio de SouzaDepartment of Immunology, University of Sao Paulo, Sao Paulo, Brazil.
Fabrício O SoutoInstitute Keizo Asami, Federal University of Pernambuco, Pernambuco, Brazil.
Joerg M BuescherMetabolomics Facility, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Joy Edwards-HicksDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Erika L PearceDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Edward J PearceDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Niels Olsen Saraiva CamaraDepartment of Immunology, University of Sao Paulo, Sao Paulo, Brazil.
Max Planck Institute of Immunobiology and Epigenetics · DEBloomberg (United States) · USUniversidade de São Paulo · BRUniversidade Federal de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Little is known about the effects of high-fat diet (HFD)-induced obesity on resident colonic lamina propria (LP) macrophages (LPMs) function and metabolism. Here, we report that obesity and diabetes resulted in increased macrophage infiltration in the colon. These macrophages exhibited the residency phenotype CX3CR1

Indexed as

EndocrinologyImmune responseMetabolomics

Identifiers

PMID37674984
PMCPMC10477064
OpenAlexW4386171364

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.