Evidence map›Paper›PMID 37674719›Full record

ArticleResearch square2023

A High-Performance Polymer Composite Column for Coronavirus Nucleic Acid Purification.

Akli Zarouri, Aaron M T Barnes, Hamada Aboubakr, Vinni Thekkudan Novi, Qiuchen Dong, Andrew Nelson, Sagar Goyal, Abdennour Abbas

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Akli ZarouriUniversity of Minnesota, Twin Cities.
Aaron M T BarnesUniversity of Minnesota, Twin Cities.
Hamada AboubakrUniversity of Minnesota, Twin Cities.
Vinni Thekkudan NoviUniversity of Minnesota, Twin Cities.
Qiuchen DongUniversity of Minnesota, Twin Cities.
Andrew NelsonUniversity of Minnesota, Twin Cities.
Sagar GoyalUniversity of Minnesota, Twin Cities.
Abdennour AbbasUniversity of Minnesota, Twin Cities.
University of Minnesota · US

Funding

Infectious Disease Training in Clinical InvestigationT32AI055433 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI David R Boulware · 2003 to 2026
$6.1M
NIAID NIH HHS T32 AI055433
6 · The paper itself

Abstract

Here, we report the development of a novel polymer composite (PC) purification column and kit. The performance of the PC columns was compared to conventional silica gel (SG) columns for the purification of nucleic acids from coronaviruses, including SARS-CoV-2, in 82 clinical samples. The results shows that PC-based purification outperforms silica gel (SG)-based purification by enabling a higher sensitivity (94%), accuracy (97%), and by eliminating false positives (100% selectivity). The high selectivity is critical for efficient patient triage and resource management during pandemics. Furthermore, PC-based purification exhibits three times higher analytical precision than a commonly used SG-based nucleic acid purification thereby enabling a more accurate quantification of viral loads and higher reproducibility.

Indexed as

CoronavirusNucleic acid purificationPolymer compositeRT-PCR detectionspin columns

Identifiers

PMID37674719
PMCPMC10479450
OpenAlexW4386155325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.