ArticleOpen forum infectious diseases2023
Diagnostic Stewardship: A Systematic Review and Meta-analysis of Blood Collection Diversion Devices Used to Reduce Blood Culture Contamination and Improve the Accuracy of Diagnosis in Clinical Settings.
Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- [S3 guideline on sepsis-prevention, diagnosis, therapy, and follow-up care-update 2025].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Guideline
- American Society for Microbiology evidence-based laboratory medicine practice guidelines to reduce blood culture contamination rates: a systematic review and meta-analysis.Clinical microbiology reviews · 2024Pooled it
- Comparison of blood culture contamination rates with standard practice versus two blood diversion devices at a single institution.Journal of clinical microbiology · 2026Observational
- Evaluation of a Direct-from-Blood Molecular Diagnostic Platform for Pathogen Detection in Critically Ill Patients: A Prospective Observational Cohort Study.Open forum infectious diseases · 2026Article
- Initial Specimen Diversion Devices for Emergency Department Blood Cultures May Reduce Contamination Rates and Costs: Structured Literature Review.The western journal of emergency medicine · 2026Review
- Efficacy of a small-volume blood culture diversion device across three wards: a 6-month retrospective review.Microbiology spectrum · 2026Article
- Clinician perspectives on blood culture practice and diagnostic stewardship in regional emergency departments.Journal of medical microbiology · 2026Article
- Application of the Blood Culture Train model based on procedural and behavioural interventions to improve the quality of blood culture collection.Infection prevention in practice · 2026Article
- Factors associated with positive blood cultures in children in nine African and Asian countries: the ACORN2 surveillance network.BMJ global health · 2025Article
- Microbiological diagnostics and their impact on hematology nursing.Folia microbiologica · 2025Review
- Decreasing blood culture contamination rates in a rural emergency department: a quality improvement initiative.BMJ open quality · 2025Article
- Impact of Initial Specimen Diversion Technique on Blood Culture Contamination Rates.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2025Article
- Blood Culture Contamination Creep Independent of COVID-19 Pandemics: An Interrupted Time-Series Analysis.Antibiotics (Basel, Switzerland) · 2025Article
- A review of implementation aspects and sustainability in the prevention of hospital onset bacteremia.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Review
- A Five-Bundle Intervention to Improve Blood Culture Use in a Tertiary Hospital in Romania.Antibiotics (Basel, Switzerland) · 2024Article
- Comparing the effects of two initial specimen diversion techniques on blood culture contamination rates and clinical outcomes-a multicenter study.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Factors Associated With Blood Culture Contamination in Rural Hospitals in Japan: A Cross-Sectional Study.Cureus · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Blood culture contamination may lead to misdiagnosis, overutilization of antibiotics, and prolonged length of stay. Blood specimen diversion devices can reduce contamination rates during blood culture collection procedures. We performed a systematic literature review and meta-analysis evaluating the influence of blood specimen diversion devices in blood culture contamination rates. Methods: We searched Medline, Cumulative Index to Nursing and Allied Health Literature, Embase, Cochrane, Scopus, and Web of Science, from database inception to 1 March 2023, for studies evaluating the impact of a diversion device on blood culture contamination. Blood culture contamination was a positive blood culture with microorganisms not representative of true bacteremia, but rather introduced during collection or processing the blood sample. Random-effects models were used to obtain pooled mean differences, and heterogeneity was assessed using the Results: Of 1768 screened studies, 12 met inclusion criteria for this systematic literature review. Of them, 9 studies were included in the meta-analysis. Studies were substantially heterogeneous, but stratified analyses considering only high-quality studies revealed that venipuncture using a diversion device was associated with a significant reduction in blood culture contamination in comparison to the standard procedure of collection (pooled odds ratio [OR], 0.26 [95% confidence interval {CI}, .13-.54]; Conclusions: Blood culture diversion devices was associated with decreased contamination rates and could improve quality of care, reduce costs, and avoid unnecessary antibiotic use.
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Registered trials
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