ArticleJournal of multimorbidity and comorbidity
A conceptual framework for characterising lifecourse determinants of multiple long-term condition multimorbidity.
Article in Journal of multimorbidity and comorbidity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Life-course patterning of MLTC clusters and their patient-centred burden in depression: a population-based study using real-world data.BMJ mental health · 2026Article
- Predicting childhood overweight and obesity at school entrance using healthcare, demographic, and socioeconomic data in Wales, UK.European journal of public health · 2026Article
- Interventions to prevent and treat multiple long-term conditions and their consequences across the life course: concepts and definitions.BMC medicine · 2026Article
- Effects of household and neighbourhood attributes on four definitions of multimorbidity: a comparative multilevel analysis of linked clinical and census data of Wales.BMJ public health · 2026Article
- Predicting multiple long-term conditions with role limitation at age 46 using early-life data from the 1970 British Cohort Study.BMJ public health · 2026Article
- Article
- A Co-Produced Stakeholder Workshop to Identify Key Time Points and Targets for Life-Course Prevention of Multiple Long-Term Conditions.Health expectations : an international journal of public participation in health care and health policy · 2025Review
- Exploring the relationship between education and academic ability in childhood with healthcare utilization in adulthood: findings from the Aberdeen Children of the 1950s (ACONF).European journal of public health · 2025Article
- Article
- Mapping domains of early life determinants of future multimorbidity across three UK longitudinal cohort studies.Scientific reports · 2024Article
- Multimorbidity trajectories in early adulthood and middle age: Findings from the CARDIA prospective cohort study.Journal of multimorbidity and comorbidityArticle
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Social, biological and environmental factors in early-life, defined as the period from preconception until age 18, play a role in shaping the risk of multiple long-term condition multimorbidity. However, there is a need to conceptualise these early-life factors, how they relate to each other, and provide conceptual framing for future research on aetiology and modelling prevention scenarios of multimorbidity. We develop a conceptual framework to characterise the population-level domains of early-life determinants of future multimorbidity. Method: This work was conducted as part of the Multidisciplinary Ecosystem to study Lifecourse Determinants and Prevention of Early-onset Burdensome Multimorbidity (MELD-B) study. The conceptualisation of multimorbidity lifecourse determinant domains was shaped by a review of existing research evidence and policy, and co-produced with public involvement via two workshops. Results: Early-life risk factors incorporate personal, social, economic, behavioural and environmental factors, and the key domains discussed in research evidence, policy, and with public contributors included adverse childhood experiences, socioeconomics, the social and physical environment, and education. Policy recommendations more often focused on individual-level factors as opposed to the wider determinants of health discussed within the research evidence. Some domains highlighted through our co-production process with public contributors, such as religion and spirituality, health screening and check-ups, and diet, were not adequately considered within the research evidence or policy. Conclusions: This co-produced conceptualisation can inform research directions using primary and secondary data to investigate the early-life characteristics of population groups at risk of future multimorbidity, as well as policy directions to target public health prevention scenarios of early-onset multimorbidity.
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