ArticleBMC genomics2023
The mitochondrial genome of the mountain wooly tapir, Tapirus pinchaque and a formal test of the effect of altitude on the adaptive evolution of mitochondrial protein coding genes in odd-toed ungulates.
Article in BMC genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 21 citations in OpenAlex.
- Mitogenome Characterization and Phylogenetic Insights Into Blind Mole Rats,Ecology and evolution · 2026Article
- Insights into the mitochondrial genomes of Taenia tapeworms.Molecular biology reports · 2026Review
- Integrative taxonomic revision of three Camellia species from section Tuberculata (Camellia, Theaceae) by morphological, anatomical, palynological, and molecular evidence.Botanical studies · 2026Article
- Review: Genomic insights into the adaptive traits and stress resistance in modern horses.Stress biology · 2026Review
- The Complete Mitochondrial Genome of the Deep-Dwelling GobyInternational journal of molecular sciences · 2025Article
- Stronger Evidence for Relaxed Selection Than Adaptive Evolution in High-elevation Animal mtDNA.Molecular biology and evolution · 2025Article
- Equus mitochondrial pangenome reveals independent domestication imprints in donkeys and horses.Scientific reports · 2025Article
- Characterization of Complete Mitochondrial Genome of Badri Breed of Bos indicus (Bovidae: Bovinae): Selection Pressure and Comparative Analysis.Biochemical genetics · 2025Article
- The first complete mitochondrial genome of Sumatran striped rabbit Nesolagus netscheri (Schlegel, 1880), and its phylogenetic relationship with other Leporidae.Scientific reports · 2025Article
- Assembly of Mitochondrial Genomes Using Nanopore Long-Read Technology in Three Sea Chubs (Teleostei: Kyphosidae).Molecular ecology resources · 2025Article
- Complete organelle genomes of the threatened aquatic speciesEcology and evolution · 2024Article
- Mitochondrial genome structure and composition in 70 fishes: a key resource for fisheries management in the South Atlantic.BMC genomics · 2024Article
- Stronger evidence for relaxed selection than adaptive evolution in high-elevation animal mtDNA.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe harsh conditions of high-altitude environments are known to drive the evolution of physiological and morphological traits in endothermic animals. These conditions are expected to result in the adaptive evolution of protein coding genes encoded in mitochondrial genomes that are vital for the oxidative phosphorylation pathway. In this study, we formally tested for signatures of adaptive evolution on mitochondrial protein coding genes in Tapirus pinchaque and other odd-toed ungulates inhabiting high-elevation environments.
resultsThe AT-rich mitochondrial genome of T. pinchaque is 16,750 bp long. A phylomitogenomic analysis supports the monophyly of the genus Tapirus and families in the Perissodactyla. The ratio of non-synonymous to synonymous substitutions demonstrated that all mitochondrial genes undergo purifying selection in T. pinchaque and other odd ungulates living at high elevations. Over this negative background selection, Branch Models suggested that cox3 and nad6 might be undergoing stronger purifying selection than other mitochondrial protein coding genes. Furthermore, Site Models suggested that one and four sites in nad2 and nad5, respectively, could be experiencing positive selection. However, these results were supported by Likelihood Ratio Tests but not Bayesian Empirical Bayes posterior probabilities. Additional analyses (in DataMonkey) indicated a relaxation of selection strength in nad6, evidence of episodic diversifying selection in cob, and revealed episodic positive/diversifying selection signatures for two sites in nad1, and one site each in nad2 and nad4.
conclusionThe mitochondrial genome of T. pinchaque is an important genomic resource for conservation of this species and this study contributes to the understanding of adaptive evolution of mitochondrial protein coding genes in odd-toed ungulates inhabiting high-altitude environments.
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