Evidence map›Paper›PMID 37674055›Full record

ArticleSurgical endoscopy2023

Transoral gastric outlet reduction for post-prandial hypoglycemia after Roux-en-Y gastric bypass.

Samuel Hunter Dunn, Sanaa Tejani, Jaime P Almandoz, Sarah E Messiah, Jeffrey Schellinger, Elisa Morales Marroquin, Matthew Mathew, Jay Horton, Anna Tavakkoli

Open access · greenAbstract read
In one paragraph

Article in Surgical endoscopy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Diagnosis and Management of Post-Bariatric Hypoglycemia.Journal of the American Board of Family Medicine : JABFM
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Samuel Hunter DunnDivision of Digestive and Liver Diseases, University of Texas Southwestern, Dallas, TX, USA. shdunn10@gmail.com.ORCID 0000-0003-1878-7916
Sanaa TejaniDepartment of Internal Medicine, University of Texas Southwestern, Dallas, TX, USA.
Jaime P AlmandozDivision of Endocrinology, University of Texas Southwestern, Dallas, TX, USA.
Sarah E MessiahUniversity of Texas Health Science Center at Houston School of Public Health, Dallas Campus, Dallas, TX, USA.
Jeffrey SchellingerDivision of Endocrinology, University of Texas Southwestern, Dallas, TX, USA.
Elisa Morales MarroquinDepartment of Nutritional Sciences, Texas Christian University, Fort Worth, TX, USA.
Matthew MathewDivision of Digestive and Liver Diseases, University of Texas Southwestern, Dallas, TX, USA.
Jay HortonDivision of Digestive and Liver Diseases, University of Texas Southwestern, Dallas, TX, USA.
Anna TavakkoliDivision of Digestive and Liver Diseases, University of Texas Southwestern, Dallas, TX, USA.
The University of Texas Southwestern Medical Center · USTexas Christian University · USUniversity of Texas Health Science Center at Dallas · US

Funding

UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4M
Evaluation of Multi-level factors Associated with post-ERCP OutcomesK23DK132409 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Anna Tavakkoli · 2023 to 2026
$638k
NIDDK NIH HHS K23 DK132409NIDDK NIH HHS P30 DK127984
6 · The paper itself

Abstract

backgroundPost-prandial hypoglycemia is an uncommon but disabling late complication of Roux-en-Y gastric bypass (RYGB). Most patients can be treated with dietary interventions and medications; however, some patients develop refractory hypoglycemia that may lead to multiple daily episodes and seizures. While RYGB reversal surgery is an effective treatment, complication rates are high, and patients inevitably experience weight regain. Transoral gastric outlet reduction (TORe) is a minimally invasive treatment that is effective for early and late dumping syndrome. However, prior studies have not distinguished the effectiveness of TORe specifically for patients with post-prandial hypoglycemia. This study aims to describe a single institution's experience of TORe for treating post-prandial hypoglycemia.

methodsThis is a case series of patients with prior RYGB complicated by post-prandial hypoglycemia who underwent TORe from February 2020 to September 2021. Pre-procedural characteristics and post-procedural outcomes were obtained. Outcomes assessed included post-prandial hypoglycemia episodes, dumping syndrome symptoms, and weight change.

resultsA total of 11 patients underwent TORe from 2020 to 2021 for post-prandial hypoglycemia. Three (27%) patients had a history of seizures due to hypoglycemia. All had been advised on dietary changes, and ten patients (91%) were on medications for dumping. All patients reported a reduction in post-prandial hypoglycemic events as well as the majority of dumping syndrome symptoms during an average follow-up time of 409 ± 125 days. Ten patients (91%) had experienced weight regain from their post-RYGB nadir weight. For these patients, the average total body weight loss 12 months post-TORe was 12.4 ± 12%. There were no complications requiring hospitalization. One patient experienced post-TORe nausea and vomiting requiring dilation of the gastrojejunal anastomosis with resolution in symptoms.

conclusionTORe is a safe and effective treatment for post-prandial hypoglycemia and weight regain after RYGB in patients with symptoms refractory to medications and dietary changes.

Indexed as

Gastric BypassHypoglycemiaObesity, MorbidDumping SyndromeHumansReoperationRetrospective StudiesSeizuresTreatment OutcomeWeight GainBariatric endoscopyDumping syndromeEndoscopic transoral outlet reductionGastric bypassHypoglycemiaObesity

Identifiers

PMID37674055
PMCPMC11930351
OpenAlexW4386471217

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.