Evidence map›Paper›PMID 37674046›Full record

ArticleJournal of cardiovascular translational research2023

Noninvasive Electrical Mapping Compared with the Paced QRS Complex for Optimizing CRT Programmed Settings and Predicting Multidimensional Response.

Frances L Morales, Derek J Bivona, Mohamad Abdi, Rohit Malhotra, Oliver Monfredi, Andrew Darby, Pamela K Mason, J Michael Mangrum, Sula Mazimba, Robert W Stadler and 3 more

Abstract read
In one paragraph

Article in Journal of cardiovascular translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Frances L MoralesUniversity of Virginia Health System, Charlottesville, VA, 22901, USA.
Derek J BivonaUniversity of Virginia Health System, Charlottesville, VA, 22901, USA.
Mohamad AbdiUniversity of Virginia Health System, Charlottesville, VA, 22901, USA.
Rohit MalhotraUniversity of Virginia Health System, Charlottesville, VA, 22901, USA.
Oliver MonfrediUniversity of Virginia Health System, Charlottesville, VA, 22901, USA.
Andrew DarbyUniversity of Virginia Health System, Charlottesville, VA, 22901, USA.
Pamela K MasonUniversity of Virginia Health System, Charlottesville, VA, 22901, USA.
J Michael MangrumUniversity of Virginia Health System, Charlottesville, VA, 22901, USA.
Sula MazimbaUniversity of Virginia Health System, Charlottesville, VA, 22901, USA.
Robert W StadlerMedtronic plc., Mounds View, MN, USA.
Frederick H EpsteinUniversity of Virginia Health System, Charlottesville, VA, 22901, USA.
Kenneth C BilchickUniversity of Virginia Health System, Charlottesville, VA, 22901, USA. kcb7f@uvahealth.org.ORCID 0000-0002-5188-3603
Pim J A OomenDepartment of Biomedical Engineeering, Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center, University of California, Irvine, Irvine, CA, USA.

Funding

Multiscale Models for Predicting Short and Long-term Outcome of Cardiac Resynchronization TherapyR01HL159945 · NHLBI · UNIVERSITY OF VIRGINIA · PI BILCHICK, KENNETH C, HOLMES, JEFFREY W · 2021 to 2024
$2.6M
NHLBI NIH HHS R01 HL159945
6 · The paper itself

Abstract

The aim was to test the hypothesis that left ventricular (LV) and right ventricular (RV) activation from body surface electrical mapping (CardioInsight 252-electrode vest, Medtronic) identifies optimal cardiac resynchronization therapy (CRT) pacing strategies and outcomes in 30 patients. The LV80, RV80, and BIV80 were defined as the times to 80% LV, RV, or biventricular electrical activation. Smaller differences in the LV80 and RV80 (|LV80-RV80|) with synchronized LV pacing predicted better LV function post-CRT (p = 0.0004) than the LV-paced QRS duration (p = 0.32). Likewise, a lower RV80 was associated with a better pre-CRT RV ejection fraction by CMR (r =  - 0.40, p = 0.04) and predicted post-CRT improvements in myocardial oxygen uptake (p = 0.01) better than the biventricular-paced QRS (p = 0.38), while a lower LV80 with BIV pacing predicted lower post-CRT B-type natriuretic peptide (BNP) (p = 0.02). RV pacing improved LV function with smaller |LV80-RV80| (p = 0.009). In conclusion, 3-D electrical mapping predicted favorable post-CRT outcomes and informed effective pacing strategies.

Indexed as

Cardiac Resynchronization TherapyHeart FailureCardiac Resynchronization Therapy DevicesHeart VentriclesHumansTreatment OutcomeVentricular Function, LeftCardiac magnetic resonanceCardiac resynchronization therapyElectrical mappingHeart failureRight ventricular function

Identifiers

PMID37674046
PMCPMC10721664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.