ArticleScientific reports2023
Surgical site infection and antimicrobial prophylaxis prescribing profile, and its determinants among hospitalized patients in Northeast Ethiopia: a hospital based cross-sectional study.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Inappropriate antibiotic prescribing in Ethiopian hospitals: a systematic review.International journal of clinical pharmacy · 2026Pooled it
- Improving antibiotic utilization in West Africa: enhancing interventions through systematic review and evidence synthesis.Antimicrobial resistance and infection control · 2025Pooled it
- Embedding locally tailored antimicrobial prophylaxis into standardized order sets for urological procedures reduces antimicrobial use.JAC-antimicrobial resistance · 2026Article
- Inappropriate antibiotic utilization in hospitalized patients in Ethiopia: A systematic review and meta-analysis.Exploratory research in clinical and social pharmacy · 2026Review
- Evaluation of inpatient antibiotic prescribing patterns using WHO indicators in Northern Ethiopia: a prospective cross-sectional study identifying stewardship gaps.BMC research notes · 2026Article
- Infection control and wound care innovations in plastic surgery: a multidisciplinary approach.Folia microbiologica · 2026Review
- Antibiotic usage in surgical prophylaxis: surveillance of clean and clean-contaminated surgeries in a tertiary care hospital.Frontiers in public health · 2026Observational
- Surgical Antibiotic Prophylaxis Utilization and Predictors of Surgical Site Infections at Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia: Prospective Cohort Study.BioMed research international · 2026Article
- Trends in morbidity and mortality from bacterial infections in hospitals in Northwest Ethiopia.BMC infectious diseases · 2025Article
- Impact of Antibiotic Prophylaxis Duration on the Incidence of Healthcare-Associated Infections in Elective Colorectal Surgery.Antibiotics (Basel, Switzerland) · 2025Article
- Surgical site infection among hospitalized patients in palestine: association with in-hospital preoperative time stay, biological and clinical characteristics.BMC research notes · 2025Article
- Model-informed dose optimization for prophylactic piperacillin-tazobactam in perioperative pediatric critically ill patients.Antimicrobial agents and chemotherapy · 2025Article
- Surgical Antimicrobial Prophylaxis in Orthopedic Implant Surgeries: An Analysis of Practices, Outcomes, and Costs.Indian journal of orthopaedics · 2025Article
- A qualitative study on factors influencing health workers' uptake of a pilot surgical antibiotic prophylaxis stewardship programme in selected Georgian hospitals.PLOS global public health · 2025Article
- Antibiotic prophylaxis practice in gastrointestinal surgery in five hospitals in southern Benin.Infection prevention in practice · 2024Article
- Orthopedic postoperative infection profile and antibiotic sensitivity of 2038 patients across 24 countries - Call for region and institution specific surgical antimicrobial prophylaxis.Journal of orthopaedics · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inappropriate use of surgical antimicrobial prophylaxis is a common cause for increased risk of morbidity and mortality from surgical site infection in patients who underwent surgical procedures. The study aimed to evaluate surgical antimicrobial prophylaxis prescribing patterns, Surgical Site Infection (SSI), and its determinants in the surgical ward of Debre Berhan Comprehensive Specialized Hospital, northeast Ethiopia. A prospective cross-sectional study was conducted from October 1st 2022 to January 31st, 2023. Data collected from patient medical record cards and patient interviews were entered and analyzed using SPSS V26.0. The determinants of surgical site infection were determined from the multivariable logistic regression. P-value ≤ 0.05 was considered statistically significant. Ceftriaxone (70.5%) followed by a combination of ceftriaxone with metronidazole (21.90%) was the most frequently used prophylactic antibiotic. One hundred fifty-nine (78%) of patients were exposed to inappropriately used prophylactic antimicrobials and 62.2% of these were exposed to inappropriately selected antibiotics. One hundred twenty-six (61.9%) patients developed Surgical Site Infection (SSI). Duration of procedure longer than an hour and inappropriate use of antimicrobial prophylaxiswere the independent predictors for the occurrence of surgical site infections. Patients whose operation was lasted in longer than an hour were 3.39 times more likely to develop SSI compared to those whose operation was completed in less than an hour, AOR = 3.39 (95% CI: 1.24-9.30). Similarly, controlling the effect of other covariate variables, individuals who were given inappropriate antimicrobial prophylaxis were 6.67 times more likely to develop SSI compared to those given appropriate prophylaxis, AOR = 6.67 (95% CI: 1.05-42.49). The high rate of SSI requires due attention from clinicians as well as health policymakers. Duration of surgical procedure greater than an hour and inappropriate antimicrobial prophylaxis use was the independent predictor of surgical site infections.
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