ArticleCommunications biology2023
Reward expectation enhances action-related activity of nigral dopaminergic and two striatal output pathways.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Temporally Coordinated Activity among Motor Cortex, Thalamus, and Thalamic Reticular Nucleus Neurons during Rat Forelimb Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Learning-dependent 4 Hz synchronization in the posterior striatum, lateral geniculate nucleus, and visual cortex.iScience · 2025Article
- Neurodegenerative Disease Movement Disorders and Dorsal Striatum-Mediated Imbalance of Habitual Motor Sequences.Molecular neurobiology · 2025Review
- Dorsomedial striatum monitors unreliability of current action policy and probes alternative one via the indirect pathway.Science advances · 2025Article
- From avoidance to new action: the multifaceted role of the striatal indirect pathway.Nature reviews. Neuroscience · 2025Review
- Modulation of Hippocampal Sharp-Wave Ripples by Behavioral States and Body Movements in Head-Fixed Rodents.eNeuro · 2025Article
- Hippocampal Sharp-Wave Ripples Decrease during Physical Actions Including Consummatory Behavior in Immobile Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Fluorescence detection of dopamine signaling to the primate striatum in relation to stimulus-reward associations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Free will: An Example of the Dopaminergic System.Integrative psychological & behavioral science · 2024Review
- Dopamine Dysregulation in Reward and Autism Spectrum Disorder.Brain sciences · 2024Review
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons comprising nigrostriatal system play important roles in action selection. However, it remains unclear how this system integrates recent outcome information with current action (movement) and outcome (reward or no reward) information to achieve appropriate subsequent action. We examined how neuronal activity of substantia nigra pars compacta (SNc) and dorsal striatum reflects the level of reward expectation from recent outcomes in rats performing a reward-based choice task. Movement-related activity of direct and indirect pathway striatal projection neurons (dSPNs and iSPNs, respectively) were enhanced by reward expectation, similarly to the SNc dopaminergic neurons, in both medial and lateral nigrostriatal projections. Given the classical basal ganglia model wherein dopamine stimulates dSPNs and suppresses iSPNs through distinct dopamine receptors, dopamine might not be the primary driver of iSPN activity increasing following higher reward expectation. In contrast, outcome-related activity was affected by reward expectation in line with the classical model and reinforcement learning theory, suggesting purposive effects of reward expectation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.