ArticleNature communications2023
A fungal sesquiterpene biosynthesis gene cluster critical for mutualist-pathogen transition in Colletotrichum tofieldiae.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Transposable Element-Driven Genomic Plasticity: Unveiling the Evolutionary Mechanisms of Lifestyle Transition and Ecological Adaptation in Endophytic Fungi.Journal of fungi (Basel, Switzerland) · 2026Article
- Characterization of anticariogenic mycosymbiotic fungi associated with the medicinal plant Piper crocatum.Scientific reports · 2026Article
- Genus-wide comparative genomics ofIMA fungus · 2026Article
- Starve or share? Phosphate availability shapes plant-microbe interactions.PLoS pathogens · 2025Article
- Article
- Dynamic shifts in plant-microbe relationships.Plant biotechnology (Tokyo, Japan) · 2025Article
- The Novel DiseaseJournal of fungi (Basel, Switzerland) · 2025Article
- Starship giant transposons dominate plastic genomic regions in a fungal plant pathogen and drive virulence evolution.Nature communications · 2025Article
- Uncovering the Host Range-Lifestyle Relationship in the Endophytic and Anthracnose Pathogenic GenusMicroorganisms · 2025Review
- Epigenetic landscape underlying plant-microbiome chemical communication.The ISME journal · 2025Review
- A fusarioid fungus forms mutualistic interactions with poplar trees that resemble ectomycorrhizal symbiosis.IMA fungus · 2025Article
- Article
- Metabolic modelling uncovers the complex interplay between fungal probiotics, poultry microbiomes, and diet.Microbiome · 2024Article
- Limited Effectiveness ofFoods (Basel, Switzerland) · 2024Article
- Modulation of plant immunity and biotic interactions under phosphate deficiency.Journal of plant research · 2024Review
- Endophytic fungi are able to induce tolerance to salt stress in date palm seedlings (Phoenix dactylifera L.).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Genome evolution and transcriptome plasticity is associated with adaptation to monocot and dicot plants in Colletotrichum fungi.GigaScience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant-associated fungi show diverse lifestyles from pathogenic to mutualistic to the host; however, the principles and mechanisms through which they shift the lifestyles require elucidation. The root fungus Colletotrichum tofieldiae (Ct) promotes Arabidopsis thaliana growth under phosphate limiting conditions. Here we describe a Ct strain, designated Ct3, that severely inhibits plant growth. Ct3 pathogenesis occurs through activation of host abscisic acid pathways via a fungal secondary metabolism gene cluster related to the biosynthesis of sesquiterpene metabolites, including botrydial. Cluster activation during root infection suppresses host nutrient uptake-related genes and changes mineral contents, suggesting a role in manipulating host nutrition state. Conversely, disruption or environmental suppression of the cluster renders Ct3 beneficial for plant growth, in a manner dependent on host phosphate starvation response regulators. Our findings indicate that a fungal metabolism cluster provides a means by which infectious fungi modulate lifestyles along the parasitic-mutualistic continuum in fluctuating environments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.