Evidence map›Paper›PMID 37673402›Full record

ArticleInternational journal of cardiology2023

Myocardial extracellular volume fraction is positively associated with activated monocyte subsets among cART-treated persons living with HIV in South Africa.

Tess E Peterson, Muki Shey, Nomawethu Masina, Lye-Yeng Wong, Scott R Shuldiner, Julian Wolfson, Stephen Jermy, Hadil Saad, Mbalabu A J Lumbamba, Achita Singh and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Tess E PetersonDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA. Electronic address: tpeter34@jhmi.edu.
Muki SheyDepartment of Medicine, University of Cape Town, Cape Town, South Africa; Wellcome Centre for Infectious Diseases Research in Africa, Cape Town, South Africa.
Nomawethu MasinaWellcome Centre for Infectious Diseases Research in Africa, Cape Town, South Africa.
Lye-Yeng WongDepartment of Surgery, Oregon Health and Science University, Portland, OR, USA.
Scott R ShuldinerVascular and Interventional Radiology, Kaiser Permanente, Los Angeles Medical Center, Los Angeles, CA, USA.
Julian WolfsonSchool of Public Health, University of Minnesota, Minneapolis, MN, USA.
Stephen JermyDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
Hadil SaadDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
Mbalabu A J LumbambaDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
Achita SinghDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
Graeme MeintjesDepartment of Medicine, University of Cape Town, Cape Town, South Africa; Wellcome Centre for Infectious Diseases Research in Africa, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, UCT, Cape Town, South Africa.
Ntobeko A B NtusiDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
Mpiko NtsekheDepartment of Medicine, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, UCT, Cape Town, South Africa.
Jason V BakerHennepin Healthcare Research Institute, Division of Infectious Diseases, Minneapolis, MN, USA; Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
University of Cape Town · ZAUniversity of Minnesota · USJohns Hopkins University · USKaiser Permanente · USOregon Health & Science University · USWellcome Centre for Infectious Diseases Research in Africa · ZA

Funding

PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
Cardiovascular Disease Epidemiology &Prevention TrngT32HL007779 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PAMELA L. Lutsey, JAMES S PANKOW · 1994 to 2026
$9.3M
The Effects of Age and Treated HIV Infection on Myocardial Disease in South AfricaR21HL137435 · NHLBI · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI BAKER, JASON V, NTSEKHE, MPIKO · 2018 to 2019
$337k
NHLBI NIH HHS R21 HL137435NHLBI NIH HHS T32 HL007227NHLBI NIH HHS T32 HL007779Wellcome Trust 211360/Z/18/Z
6 · The paper itself

Abstract

backgroundDespite treatment with combination antiretroviral therapy (cART), persons living with HIV (PLWH) are at higher risk of cardiac structural abnormalities that may presage clinical heart failure, including myocardial fibrosis. This study assessed whether circulating cellular and soluble protein markers of immune activation cross-sectionally associate with myocardial fibrosis among cART-treated PLWH in South Africa.

methodsParticipants were enrolled in Khayelitsha township near Cape Town, SA. Cardiac magnetic resonance imaging was performed. Plasma protein biomarkers were measured using enzyme-linked immunoassays and monocyte phenotypes were evaluated using flow cytometry. Associations were assessed using multivariable linear and logistic regression.

resultsAmong 69 cART-treated PLWH, mean (SD) age was 48 (10) years, 71% were female, and time since HIV diagnosis was 9 (6) years. Evidence of left ventricular fibrosis by late gadolinium enhancement was present in 74% of participants and mean (SD) extracellular volume fraction (ECV) was 30.9 (5.9)%. Degree of myocardial fibrosis/inflammation measured by ECV was positively associated with percentages of circulating non-classical and intermediate monocyte phenotypes reflecting inflammation and tissue injury.

conclusionThese data generate hypotheses on possible immune mechanisms of HIV-associated non-ischemic myocardial disease, specifically among cART-treated PLWH in sub-Saharan Africa, where the majority of the HIV burden exists globally.

Indexed as

CardiomyopathiesHIV InfectionsContrast MediaFemaleFibrosisGadoliniumHumansInflammationMagnetic Resonance Imaging, CineMaleMiddle AgedMonocytesMyocardiumSouth AfricaContrast MediaGadoliniumExtracellular volume fractionHIV infectionMonocyte activationMonocyte phenotypeMyocardial fibrosis

Identifiers

PMID37673402
PMCPMC10591894
OpenAlexW4386424939

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.