ArticleOphthalmology. Retina2024
Perfused and Nonperfused Microaneurysms Identified and Characterized by Structural and Angiographic OCT.
Article in Ophthalmology. Retina, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- Islets persisting on OCT macular thickness map after intravitreal injections unmask telangiectatic capillaries (TelCaps) in diabetic macular edema.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Trial
- Automated Volumetric Segmentation of Microaneurysms on OCT Using Artificial Intelligence.ArXiv · 2026Article
- Detection of microaneurysms causing macular edema associated with branch retinal vein occlusion using optical coherence tomography and optical coherence tomography angiography and the effect of focal photocoagulation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Microaneurysm segmentation under out-of-domain generalization: from diabetic retinopathy to leukemic retinopathy.International journal of retina and vitreous · 2026Article
- Macular Microaneurysms Are Associated With Chronic Kidney Disease and Deep Capillary Plexus Ischemia in Referable Diabetic Retinopathy.Investigative ophthalmology & visual science · 2025Article
- Quantifying Choriocapillaris Flow Deficits in Diabetic Retinopathy Using Projection-Resolved OCT Angiography.Investigative ophthalmology & visual science · 2025Article
- Ultra-Widefield Retinal Optical Coherence Tomography (OCT) and Angio-OCT Using an Add-On Lens.Diagnostics (Basel, Switzerland) · 2025Article
- Widefield OCT angiography.Progress in retinal and eye research · 2025Review
- Nonperfused Retinal Capillaries-A New Method Developed on OCT and OCTA.Investigative ophthalmology & visual science · 2025Article
- Advances in OCT Angiography.Translational vision science & technology · 2025Review
- Evaluating Blood Flow Speed in Retinal Microaneurysms Secondary to Diabetic Retinopathy Using Variable Interscan Time Analysis OCTA.Translational vision science & technology · 2025Article
- The novel antidiabetic medications on diabetic retinopathy: relevant molecular mechanisms, advancing diagnostic innovations, and therapeutic implications.Frontiers in medicine · 2025Review
- Digital histology of retinal microaneurysms as provided by dense B-scan (DART) OCTA: characteristics and clinical relevance in diabetic retinopathy.Eye (London, England) · 2024Observational
- Optical coherence tomography angiography in diabetic retinopathy.Progress in retinal and eye research · 2023Review
- Turnover of Microaneurysms After Intravitreal Injections of Faricimab for Diabetic Macular Edema.Investigative ophthalmology & visual science · 2023Article
- OCT angiography and its retinal biomarkers [Invited].Biomedical optics express · 2023Review
- Advancing optical coherence tomography angiography to the clinic.Taiwan journal of ophthalmologyReview
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeMicroaneurysms (MAs) have distinct, oval-shaped, hyperreflective walls on structural OCT, and inconsistent flow signal in the lumen with OCT angiography (OCTA). Their relationship to regional macular edema in diabetic retinopathy (DR) has not been quantitatively explored.
designRetrospective, cross-sectional study.
participantsA total of 99 participants, including 23 with mild, nonproliferative DR (NPDR), 25 with moderate NPDR, 34 with severe NPDR, and 17 with proliferative DR.
methodsWe obtained 3 × 3-mm scans with a commercial device (Solix, Visionix/Optovue) in 99 patients with DR. Trained graders manually identified MAs and their location relative to the anatomic layers from cross-sectional OCT. Microaneurysms were first classified as perfused if flow signal was present in the OCTA channel. Then, perfused MAs were further classified into fully and partially perfused MAs based on the flow characteristics in en face OCTA. The presence of retinal fluid based on OCT near MAs was compared between perfused and nonperfused types. We also compared OCT-based MA detection to fundus photography (FP)- and fluorescein angiography (FA)-based detection.
main outcome measuresOCT-identified MAs can be classified according to colocalized OCTA flow signal into fully perfused, partially perfused, and nonperfused types. Fully perfused MAs may be more likely to be associated with diabetic macular edema (DME) than those without flow.
resultsWe identified 308 MAs (166 fully perfused, 88 partially perfused, 54 nonperfused) in 42 eyes using OCT and OCTA. Nearly half of the MAs identified in this study straddle the inner nuclear layer and outer plexiform layer. Compared with partially perfused and nonperfused MAs, fully perfused MAs were more likely to be associated with local retinal fluid. The associated fluid volumes were larger with fully perfused MAs compared with other types. OCT/OCTA detected all MAs found on FP. Although not all MAs seen with FA were identified with OCT, some MAs seen with OCT were not visible with FA or FP.
conclusionsOCT-identified MAs with colocalized flow on OCTA are more likely to be associated with DME than those without flow. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.