Evidence map›Paper›PMID 37673369›Full record

ArticleExperimental parasitology2023

Changes in oxygen delivery during experimental models of cerebral malaria.

Vinay P Jani, Alexander T Williams, Leonardo Carvalho, Pedro Cabrales

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental parasitology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Vinay P JaniDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, 92093-0412, USA.
Alexander T WilliamsDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, 92093-0412, USA.
Leonardo CarvalhoInstituto Oswaldo Cruz, Fio Cruz Rio de Janeiro, Brazil; La Jolla Bioengineering Institute, 505 Coast Boulevard South, Suite 406, La Jolla, CA, 92037, USA.
Pedro CabralesDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, 92093-0412, USA. Electronic address: pcabrales@ucsd.edu.
University of California San Diego · USFaculdades Oswaldo Cruz · BR

Funding

Bioengineering a Dual Function Protein Construct to Detoxify Heme and HemoglobinR01HL159862 · NHLBI · OHIO STATE UNIVERSITY · PI BUEHLER, PAUL WERNER, CABRALES, PEDRO · 2021 to 2024
$2.6M
Bioengineering a novel therapeutic protein complex to minimize the effects of medical device induced hemolysisR01HL162120 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI BUEHLER, PAUL WERNER, CABRALES, PEDRO · 2022 to 2025
$2.6M
Attenuating the Oxidative and Myocardial Side-Effects of Acellular HemoglobinR01HL126945 · NHLBI · OHIO STATE UNIVERSITY · PI CABRALES, PEDRO, PALMER, ANDRE FRANCIS · 2016 to 2019
$1.7M
NHLBI NIH HHS R01 HL126945NHLBI NIH HHS R01 HL159862NHLBI NIH HHS R01 HL162120
6 · The paper itself

Abstract

Cerebral malaria (CM) is a severe manifestation of malaria that commonly occurs in children and is hallmarked by neurologic symptoms and significant Plasmodium falciparum parasitemia. It is currently hypothesized that cerebral hypoperfusion from impaired microvascular oxygen transport secondary to parasitic occlusion of the microvasculature is responsible for cerebral ischemia and thus disease severity. Animal models to study CM, are known as experimental cerebral malaria (ECM), and include the C57BL/6J infected with Plasmodium berghei ANKA (PbA), which is ECM-susceptible, and BALB/c infected with PbA, which is ECM-resistant. Here we sought to investigate whether changes in oxygen (O

Indexed as

Cerebral malariaHemodynamicsMicrocirculationOxygen affinityPhosphorescence quenching microscopy

Identifiers

PMID37673369
PMCPMC12889873
OpenAlexW4386444319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.