Evidence map›Paper›PMID 37672534›Full record

ArticlePloS one2023

Exploring the prevalence of Human Papillomavirus (HPV) genotypes in PAP smear samples of women in northern region of United Arab Emirates (UAE): HPV Direct Flow CHIP system-based pilot study.

Heba Issa Odeh, Sara Rashid Al-Badi, Basma Karima, Takrim Abdulwali Saeed, Nazeerullah Rahamathullah, Eman Hassan Ibrahim, May Khalil Ismail, Zahra Arshad Khan

Open access · goldAbstract read
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Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Heba Issa OdehDepartment of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates.ORCID 0000-0001-6352-044X
Sara Rashid Al-BadiDepartment of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates.ORCID 0000-0002-5764-0899
Basma KarimaDepartment of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates.
Takrim Abdulwali SaeedDepartment of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates.
Nazeerullah RahamathullahDepartment of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates.ORCID 0000-0001-8659-3780
Eman Hassan IbrahimDepartment of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates.
May Khalil IsmailDepartment of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates.ORCID 0000-0003-3408-8971
Zahra Arshad KhanDepartment of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates.ORCID 0000-0001-8094-8595
Gulf Medical University · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to explore the prevalence of low and high-risk HPV genotypes in PAP smear samples of women in northern region of the UAE using HPV direct flow CHIP method.

methodsA cross-sectional retrospective study was conducted between September 2021 to April 2022. A total of 104 liquid-based cervical cytology samples were obtained from women aged 20-59 years attending the Gynaecology out-patient department of Thumbay University Hospital and other hospitals of Northern Emirates of UAE, processed for the routine cytological examination to identify and differentiate morphological changes of the PAP smear samples. HPV genotyping was performed using HPV direct flow CHIP method.

resultsIn total, 112 HPV genotypes were detected in 63 women (60.57%) included 18 abnormal cytological and 45 normal epithelial samples. 63 LR and 49 HR HPV genotypes were identified in all the 63 positive samples. Highest rate of infection with multiple LR and HR HPV genotypes were detected in women aged 40-49 years (25.9%) and 20-29 years (23.5%). Infection by HPV6 (13.46%), HPV11 (9.61%), HPV16 (9.61%), HPV62/81 (7.69%) and HPV45 (7.69%) were the most common genotypes. A moderate increase than expected incidence of HPV45 and 62/81 (7.69%) were detected. Co-infection with multiple low and high-risk genotypes is present in 20.2% cases; in that, HPV6 (15.9%) was the most common followed by HPV62/81 (12.7%) and HPV16 (11.11%). The prevalence of HPV18 was found to be 1.6%.

conclusionThe genotypes 6, 45, 16, 11, 67, 62/81 were the most common HPV infections in the women between the age group of 21 and 59-years-old. A moderate increase of HPV45, 62/81 and much less prevalence of HPV18 were detected in the study population. 43.27% of the normal epithelia were positive to different low and high-risk HPV genotypes. This finding highlights the importance of molecular genotyping of HPV to emphasize the cervical screening triage.

Indexed as

Papillomavirus InfectionsUterine Cervical NeoplasmsAdultCross-Sectional StudiesEarly Detection of CancerFemaleGenotypeHospitals, UniversityHuman papillomavirus 16Human papillomavirus 18Human Papillomavirus VirusesHumansMiddle AgedPapanicolaou TestPilot ProjectsPrevalence

Identifiers

PMID37672534
PMCPMC10482270
OpenAlexW4386470702

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.