Evidence map›Paper›PMID 37672487›Full record

ArticleAnnals of medicine2023

First detection of Varicella Zoster Virus clade 9 cases in India during mpox surveillance.

Abhinendra Kumar, Lekshmi S Rajan, Kannan Sabarinath Ps, Anita M Shete, Rima R Sahay, Deepak Y Patil, Nayana Ingole, Kaveri K, Anupama Cherayi Padinakarai, Shantala Gb and 13 more

Open access · goldAbstract read
In one paragraph

Article in Annals of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 1 country.

Abhinendra KumarIndian Council of Medical Research-National Institute of Virology, Pune, India.
Lekshmi S RajanIndian Council of Medical Research-National Institute of Virology, Pune, India.
Kannan Sabarinath PsIndian Council of Medical Research-National Institute of Virology, Pune, India.
Anita M SheteIndian Council of Medical Research-National Institute of Virology, Pune, India.
Rima R SahayIndian Council of Medical Research-National Institute of Virology, Pune, India.
Deepak Y PatilIndian Council of Medical Research-National Institute of Virology, Pune, India.
Nayana IngoleVirus Research and Diagnostic Laboratory, Kasturba Hospital for Infectious Diseases, Mumbai, India.
Kaveri KKing Institute of Preventive Medicine and Research, Chennai, India.
Anupama Cherayi PadinakaraiKing Institute of Preventive Medicine and Research, Chennai, India.
Shantala GbBangalore Medical College and Research Institute, Bengaluru, India.
Jayanthi ShastriVirus Research and Diagnostic Laboratory, Kasturba Hospital for Infectious Diseases, Mumbai, India.
Shashiraja PadukoneBangalore Medical College and Research Institute, Bengaluru, India.
Yash JoshiIndian Council of Medical Research-National Institute of Virology, Pune, India.
Savita PatilIndian Council of Medical Research-National Institute of Virology, Pune, India.
Triparna MajumdarIndian Council of Medical Research-National Institute of Virology, Pune, India.
Ajay VermaIndian Council of Medical Research-National Institute of Virology, Pune, India.
Jyoti YemulIndian Council of Medical Research-National Institute of Virology, Pune, India.
Nandini ShendeIndian Council of Medical Research-National Institute of Virology, Pune, India.
Vaishnavi KumariIndian Council of Medical Research-National Institute of Virology, Pune, India.
Pratiksha VedpathakIndian Council of Medical Research-National Institute of Virology, Pune, India.
Shubhangi SatheIndian Council of Medical Research-National Institute of Virology, Pune, India.
Pranita GawandeIndian Council of Medical Research-National Institute of Virology, Pune, India.
Pragya D YadavIndian Council of Medical Research-National Institute of Virology, Pune, India.
ICMR-National Institute of Virology · INBangalore Medical College and Research Institute · INKasturba Hospital · INKing Institute of Preventive Medicine and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe multi-country mpox outbreak across the globe has led to the systematic surveillance of mpox cases in India. During the surveillance of mpox, we encountered cases of Varicella Zoster Virus (VZV) in suspected mpox cases amongst children & adults. This study focused on the genomic characterization of VZV in India.

methodsA total of 331 mpox suspected cases were tested for VZV through real-time PCR, and the positive samples were subjected to next-generation sequencing to retrieve the whole genome of VZV using CLC genomics software. Phylogenetic analysis has been done in MEGA 11.0 software to identify circulating clades.

resultOf the 331 suspected cases, 28 cases with vesicular rashes were found to be positive for VZV. The maximum genome could be retrieved from the clinical specimens of 16 cases with coverage greater than 98% when mapped with reference strain Dumas (NC 001348). The phylogenetic analyses of these sequences determined the circulation of clades 1, 5, and 9 in India. Further, the sequence analysis demonstrated non-synonymous single nucleotide polymorphism (SNPs) among specific ORF of VZV including ORF 14, ORF 22, ORF 36, ORF 37 and ORF 51. Although clade 1 and 5 has been reported earlier, the circulation of clade 9 of VZV has been determined for the first time in India.

conclusionAlthough the circulation of different clades of VZV was reported from India, the presence of clade 9 was detected for the first time during the mpox surveillance.

Indexed as

Herpesvirus 3, HumanMpox, MonkeypoxAdultChildGenomicsHumansIndiaPhylogenycladempoxsequencingsingle nucleotide polymorphismVaricella zoster virus

Identifiers

PMID37672487
PMCPMC10484040
OpenAlexW4386485651

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.