Evidence map›Paper›PMID 37672337›Full record

ArticleMolecular biology of the cell2023

Caveola mechanotransduction reinforces the cortical cytoskeleton to promote epithelial resilience.

John W Brooks, Vikas Tillu, Julia Eckert, Suzie Verma, Brett M Collins, Robert G Parton, Alpha S Yap

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Caveolae mechanics in cellular functions and disease.Nature reviews. Molecular cell biology · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

John W BrooksInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Australia 4072.
Vikas TilluInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Australia 4072.
Julia EckertInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Australia 4072.
Suzie VermaInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Australia 4072.
Brett M CollinsInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Australia 4072.
Robert G PartonInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Australia 4072.
Alpha S YapInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Australia 4072.
The University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As physical barriers, epithelia must preserve their integrity when challenged by mechanical stresses. Cell-cell junctions linked to the cortical cytoskeleton play key roles in this process, often with mechanotransduction mechanisms that reinforce tissues. Caveolae are mechanosensitive organelles that buffer tension via disassembly. Loss of caveolae, through caveolin-1 or cavin1 depletion, causes activation of PtdIns(4, 5)P

Indexed as

ActinsCaveolaeCaveolin 1CytoskeletonEpithelial CellsMechanotransduction, CellularActinsCaveolin 1

Identifiers

PMID37672337
PMCPMC10846620
OpenAlexW4386484562

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.