Evidence map›Paper›PMID 37672206›Full record

GuidelineClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2024

A genetic profiling guideline to support diagnosis and clinical management of lymphomas.

Margarita Sánchez-Beato, Miriam Méndez, María Guirado, Lucía Pedrosa, Silvia Sequero, Natalia Yanguas-Casás, Luis de la Cruz-Merino, Laura Gálvez, Marta Llanos, Juan Fernando García and 1 more

Open access · hybridAbstract readReviewPractice Guideline
In one paragraph

Guideline in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Margarita Sánchez-BeatoServicio de Oncología Médica, Grupo de Investigación en Linfomas, Hospital Universitario Puerta de Hierro-Majadahonda, IDIPHISA, Madrid, Spain. msbeato@idiphim.org.ORCID http://orcid.org/0000-0002-0058-7599
Miriam MéndezServicio de Oncología Médica, Grupo de Investigación en Linfomas, Hospital Universitario Puerta de Hierro-Majadahonda, IDIPHISA, Madrid, Spain.ORCID http://orcid.org/0000-0002-1579-5809
María GuiradoGrupo Oncológico para el Tratamiento y Estudio de los Linfomas-GOTEL, Madrid, Spain.
Lucía PedrosaServicio de Oncología Médica, Grupo de Investigación en Linfomas, Hospital Universitario Puerta de Hierro-Majadahonda, IDIPHISA, Madrid, Spain.ORCID http://orcid.org/0000-0002-7486-515X
Silvia SequeroGrupo Oncológico para el Tratamiento y Estudio de los Linfomas-GOTEL, Madrid, Spain.ORCID http://orcid.org/0000-0002-7432-4636
Natalia Yanguas-CasásServicio de Oncología Médica, Grupo de Investigación en Linfomas, Hospital Universitario Puerta de Hierro-Majadahonda, IDIPHISA, Madrid, Spain.ORCID http://orcid.org/0000-0003-4368-0176
Luis de la Cruz-MerinoGrupo Oncológico para el Tratamiento y Estudio de los Linfomas-GOTEL, Madrid, Spain.
Laura GálvezGrupo Oncológico para el Tratamiento y Estudio de los Linfomas-GOTEL, Madrid, Spain.
Marta LlanosGrupo Oncológico para el Tratamiento y Estudio de los Linfomas-GOTEL, Madrid, Spain.
Juan Fernando GarcíaServicio de Anatomía Patológica, Hospital MD Anderson Cancer Center, Madrid, Spain.ORCID http://orcid.org/0000-0001-6974-0806
Mariano ProvencioServicio de Oncología Médica, Grupo de Investigación en Linfomas, Hospital Universitario Puerta de Hierro-Majadahonda, IDIPHISA, Madrid, Spain.ORCID http://orcid.org/0000-0002-2826-656X
Hospital Universitario Puerta de Hierro Majadahonda · ESHospital Clínico Universitario Virgen de la Victoria · ESHospital General Universitario de Elche · ESHospital Universitario de Canarias · ESHospital Universitario Virgen Macarena · ESInstituto de Investigación Biosanitaria de Granada · ESMD Anderson Cancer Center Madrid · ES

Funding

Comunidad de Madrid B2017/BMD-3778Instituto de Salud Carlos III IFI18/0004Instituto de Salud Carlos III PI17/00272Instituto de Salud Carlos III PI20/00691
6 · The paper itself

Abstract

The new lymphoma classifications (International Consensus Classification of Mature Lymphoid Neoplasms, and 5th World Health Organization Classification of Lymphoid Neoplasms) include genetics as an integral part of lymphoma diagnosis, allowing better lymphoma subclassification, patient risk stratification, and prediction of treatment response. Lymphomas are characterized by very few recurrent and disease-specific mutations, and most entities have a heterogenous genetic landscape with a long tail of recurrently mutated genes. Most of these occur at low frequencies, reflecting the clinical heterogeneity of lymphomas. Multiple studies have identified genetic markers that improve diagnostics and prognostication, and next-generation sequencing is becoming an essential tool in the clinical laboratory. This review provides a "next-generation sequencing" guide for lymphomas. It discusses the genetic alterations of the most frequent mature lymphoma entities with diagnostic, prognostic, and predictive potential and proposes targeted sequencing panels to detect mutations and copy-number alterations for B- and NK/T-cell lymphomas.

Indexed as

LymphomaHumansMutationPrognosisDiagnosisLymphomaNext-generation sequencingPrognosis

Identifiers

PMID37672206
PMCPMC11026206
OpenAlexW4386467073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.