Evidence map›Paper›PMID 37672106›Full record

SynthesisJournal of neurology2023

Facial expression recognition deficits in frontotemporal dementia and Alzheimer's disease: a meta-analytic investigation of effects of phenotypic variant, task modality, geographical region and symptomatic specificity.

Daphne Stam, Simon Rosseel, François-Laurent De Winter, Maarten J A Van den Bossche, Mathieu Vandenbulcke, Jan Van den Stock

Abstract readMeta-AnalysisReview
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In one paragraph

Synthesis in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Daphne Stam *KU Leuven, Leuven Brain Institute, Neuropsychiatry, 3000, Leuven, Belgium.
Simon Rosseel *KU Leuven, Leuven Brain Institute, Neuropsychiatry, 3000, Leuven, Belgium.
François-Laurent De WinterKU Leuven, Leuven Brain Institute, Neuropsychiatry, 3000, Leuven, Belgium.
Maarten J A Van den BosscheKU Leuven, Leuven Brain Institute, Neuropsychiatry, 3000, Leuven, Belgium.
Mathieu VandenbulckeKU Leuven, Leuven Brain Institute, Neuropsychiatry, 3000, Leuven, Belgium.
Jan Van den StockKU Leuven, Leuven Brain Institute, Neuropsychiatry, 3000, Leuven, Belgium. Jan.vandenstock@kuleuven.be.ORCID http://orcid.org/0000-0001-5756-3195
KU Leuven · BEAllen Institute for Brain Science · US

Funding

KU Leuven C24/18/095KU Leuven IDN/21/010
6 · The paper itself

Abstract

Deficits in social cognition may be present in frontotemporal dementia (FTD) and Alzheimer's disease (AD). Here, we conduct a qualitative synthesis and meta-analysis of facial expression recognition studies in which we compare the deficits between both disorders. Furthermore, we investigate the specificity of the deficit regarding phenotypic variant, domain-specificity, emotion category, task modality, and geographical region. The results reveal that both FTD and AD are associated with facial expression recognition deficits, that this deficit is more pronounced in FTD compared to AD and that this applies for the behavioral as well as for language FTD-variants, with no difference between the latter two. In both disorders, overall emotion recognition was most frequently impaired, followed by recognition of anger in FTD and by fear in AD. Verbal categorization was the most frequently used task, although matching or intensity rating tasks may be more specific. Studies from Oceania revealed larger deficits. On the other hand, non-emotional control tasks were more impacted by AD than by FTD. The present findings sharpen the social cognitive phenotype of FTD and AD, and support the use of social cognition assessment in late-life neuropsychiatric disorders.

Indexed as

Alzheimer DiseaseFacial RecognitionFrontotemporal DementiaEmotionsFacial ExpressionHumansNeuropsychological TestsPhenotypeAlzheimer’s diseaseFacial expression recognitionFrontotemporal dementiaMeta-analysis

Identifiers

PMID37672106
OpenAlexW4386466677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.