Evidence map›Paper›PMID 37672050›Full record

ArticleMedical microbiology and immunology2023

Eicosapentaenoic acid influences the pathogenesis of Candida albicans in Caenorhabditis elegans via inhibition of hyphal formation and stimulation of the host immune response.

N Z Mokoena, H Steyn, A Hugo, T Dix-Peek, C Dickens, O M N Gcilitshana, O Sebolai, J Albertyn, C H Pohl

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical microbiology and immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

N Z MokoenaDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, South Africa.
H SteynDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, South Africa.
A HugoDepartment of Animal Science, University of the Free State, Bloemfontein, South Africa.
T Dix-PeekDepartment of Internal Medicine, University of Witwatersrand, Johannesburg, South Africa.
C DickensDepartment of Internal Medicine, University of Witwatersrand, Johannesburg, South Africa.
O M N GcilitshanaDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, South Africa.
O SebolaiDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, South Africa.
J AlbertynDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, South Africa.
C H PohlDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein, South Africa. PohlCH@ufs.ac.za.ORCID http://orcid.org/0000-0001-6928-5663
University of the Free State · ZAUniversity of the Witwatersrand · ZA

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

The intake of omega-3 polyunsaturated fatty acids, including eicosapentaenoic acid (EPA), is associated with health benefits due to its anti-inflammatory properties. This fatty acid also exhibits antifungal properties in vitro. In order to determine if this antifungal property is valid in vivo, we examined how EPA affects Candida albicans pathogenesis in the Caenorhabditis elegans infection model, an alternative to mammalian host models. The nematodes were supplemented with EPA prior to infection, and the influence of EPA on C. elegans lipid metabolism, survival and immune response was studied. In addition, the influence of EPA on hyphal formation in C. albicans was investigated. It was discovered that EPA supplementation changed the lipid composition, but not the unsaturation index of C. elegans by regulating genes involved in fatty acid and eicosanoid production. EPA supplementation also delayed killing of C. elegans by C. albicans due to the inhibition of hyphal formation in vivo, via the action of the eicosanoid metabolite of EPA, 17,18-epoxyeicosatetraenoic acid. Moreover, EPA supplementation also caused differential expression of biofilm-related gene expression in C. albicans and stimulated the immune response of C. elegans. This provides a link between EPA and host susceptibility to microbial infection in this model.

Indexed as

Caenorhabditis elegansEicosapentaenoic AcidAnimalsAntifungal AgentsCandida albicansFatty AcidsMammalsAntifungal AgentsEicosapentaenoic AcidFatty Acids17,18-Epoxyeicosatetraenoic acidCaenorhabditis elegansCandida albicansEicosapentaenoic acidHyphal formation

Identifiers

PMID37672050
PMCPMC10501937
OpenAlexW4386466408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.