Evidence map›Paper›PMID 37671909›Full record

ArticleThe Analyst2023

Detecting secondary structure formation with FRET-PAINT.

Sineth G Kodikara, Kylie J Merkel, Simon J Haas, Sajad Shiekh, Hamza Balci

Abstract read
In one paragraph

Article in The Analyst, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Protection of the Telomeric Junction by the Shelterin Complex.Journal of the American Chemical Society · 2024
    Article
  5. Protection of the Telomeric Junction by the Shelterin Complex.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sineth G KodikaraDepartment of Physics, Kent State University, Kent, OH, 44242, USA. hbalci@kent.edu.ORCID http://orcid.org/0000-0002-3385-6054
Kylie J MerkelDepartment of Physics, Kent State University, Kent, OH, 44242, USA. hbalci@kent.edu.
Simon J HaasDepartment of Physics, Kent State University, Kent, OH, 44242, USA. hbalci@kent.edu.
Sajad ShiekhDepartment of Physics, Kent State University, Kent, OH, 44242, USA. hbalci@kent.edu.
Hamza BalciDepartment of Physics, Kent State University, Kent, OH, 44242, USA. hbalci@kent.edu.ORCID http://orcid.org/0000-0002-0273-4871

Funding

Targeting Promoter G-quadruplexes with CRISPR-dCas9 for Transcription RegulationR15GM146180 · NIGMS · KENT STATE UNIVERSITY · PI BALCI, HAMZA · 2022 to 2023
$539k
Influence of small molecules on G-quadruplex stability, folding kinetics, and interactions with proteinsR15GM123443 · NIGMS · KENT STATE UNIVERSITY · PI BALCI, HAMZA · 2018 to 2018
$438k
NIGMS NIH HHS R15 GM123443NIGMS NIH HHS R15 GM146180
6 · The paper itself

Abstract

We present single molecule studies demonstrating the capabilities of the FRET-PAINT method to detect secondary structures that would be challenging to detect with alternative methods, particularly single molecule FRET (smFRET). Instead of relying on the change in end-to-end separation as in smFRET, we use the change in accessibility to a small probe as the criterion for secondary structure formation and relative stability. As a model system, we study G-triplex formation by human telomeric repeat sequences in different structural contexts.

Identifiers

PMID37671909
PMCPMC10561560

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.