Evidence map›Paper›PMID 37671894›Full record

ArticleJournal of the American Chemical Society2023

Enzymatic Nitrogen Incorporation Using Hydroxylamine.

Shilong Gao, Anuvab Das, Edwin Alfonzo, Kathleen M Sicinski, Dominic Rieger, Frances H Arnold

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  9. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
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  12. Article
  13. Article
  14. Article
  15. Emergent Mechanisms in Biocatalysis.ACS central science · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shilong GaoDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0003-2808-6283
Anuvab DasDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0002-9344-4414
Edwin AlfonzoDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Kathleen M SicinskiDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Dominic RiegerDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0009-0000-0265-0304
Frances H ArnoldDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0002-4027-364X
California Institute of Technology · US

Funding

Dearomatization of Planar Aromatic Cores into Three-Dimensional Scaffolds with Defined StereochemistryF32GM145123 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI SICINSKI, KATHLEEN M · 2022 to 2024
$213k
Biocatalyzed Synthesis of Chiral Trifluoroethylamines via Disparate Mechanisms of Ammonium YlidesF32GM143799 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ALFONZO, EDWIN · 2021 to 2023
$142k
NIGMS NIH HHS F32 GM143799NIGMS NIH HHS F32 GM145123
6 · The paper itself

Abstract

Hydroxylamine-derived reagents have enabled versatile nitrene transfer reactions for introducing nitrogen-containing functionalities in small-molecule catalysis, as well as biocatalysis. These reagents, however, result in a poor atom economy and stoichiometric organic waste. Activating hydroxylamine (NH

Indexed as

HydroxylaminesNitrogenAminationHydroxylamineIminesHydroxylamineHydroxylaminesIminesNitrogenphenylnitrene

Identifiers

PMID37671894
PMCPMC10560455
OpenAlexW4386466929

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.