Evidence map›Paper›PMID 37671571›Full record

ReviewHypertension (Dallas, Tex. : 1979)2024

Physiological Mechanisms of Dietary Salt Sensing in the Brain, Kidney, and Gastrointestinal Tract.

Sean D Stocker, Brian J Kinsman, William B Farquhar, Georgina Gyarmati, Janos Peti-Peterdi, Alan F Sved

Open access · greenAbstract readReview
In one paragraph

Review in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. The brain and hypertension: how the brain regulates and suffers from blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Review
  8. Article
  9. Dysregulation of the fluid homeostasis system by aging.bioRxiv : the preprint server for biology · 2024
    Article
  10. Brain Pathways in Blood Pressure Regulation.Hypertension (Dallas, Tex. : 1979) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Sean D StockerDepartment of Neurobiology, University of Pittsburgh School of Medicine, PA (S.D.S.).ORCID 0000-0001-6317-6300
Brian J KinsmanDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA (B.J.K.).
William B FarquharDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE (W.B.F.).ORCID 0000-0003-0176-4486
Georgina GyarmatiDepartment of Physiology and Neuroscience and Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA (G.G., J.P.-P.).ORCID 0000-0003-3452-7970
Janos Peti-PeterdiDepartment of Physiology and Neuroscience and Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA (G.G., J.P.-P.).ORCID 0000-0003-4092-6185
Alan F SvedDepartment of Neuroscience, University of Pittsburgh, PA (A.F.S.).
University of Pittsburgh · USUniversity of Southern California · USMassachusetts General Hospital · USUniversity of Delaware · US

Funding

Multiphoton Imaging of the Juxtaglomerular ApparatusR01DK064324 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JANOS PETI-PETERDI · 2004 to 2026
$8.4M
Novel regulatory mechanisms of the glomerular endotheliumR01DK123564 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JANOS PETI-PETERDI · 2019 to 2026
$3.5M
Forebrain electroneutral transporters in salt-sensitive hypertensionR01HL163906 · NHLBI · UNIVERSITY OF DELAWARE · PI SEAN D STOCKER, Megan M Wenner · 2023 to 2026
$2.8M
Autonomic control of kidney functionR01DK135541 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SEAN D STOCKER, Mark L. Zeidel · 2023 to 2026
$2.6M
Identification of mechano versus chemo-sensitive renal sensory neurons in hypertensionR01HL152680 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STOCKER, SEAN D · 2020 to 2023
$2.4M
Brain NaCl-sensing in salt-sensitive hypertension.R01HL145875 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STOCKER, SEAN D · 2019 to 2022
$2.2M
A new paradigm of glomerular immune cell homingR01DK135290 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JANOS PETI-PETERDI · 2023 to 2026
$1.8M
Central Sodium Sensing in Older Humans: Implications for Blood Pressure RegulationR21AG074544 · NIA · UNIVERSITY OF DELAWARE · PI FARQUHAR, WILLIAM B · 2022 to 2023
$440k
NHLBI NIH HHS R01 HL145875NHLBI NIH HHS R01 HL152680NHLBI NIH HHS R01 HL163906NIA NIH HHS R21 AG074544NIDDK NIH HHS R01 DK064324NIDDK NIH HHS R01 DK123564NIDDK NIH HHS R01 DK135290NIDDK NIH HHS R01 DK135541
6 · The paper itself

Abstract

Excess dietary salt (NaCl) intake is strongly correlated with cardiovascular disease and is a major contributing factor to the pathogenesis of hypertension. NaCl-sensitive hypertension is a multisystem disorder that involves renal dysfunction, vascular abnormalities, and neurogenically-mediated increases in peripheral resistance. Despite a major research focus on organ systems and these effector mechanisms causing NaCl-induced increases in arterial blood pressure, relatively less research has been directed at elucidating how NaCl is sensed by various tissues to elicit these downstream effects. The purpose of this review is to discuss how the brain, kidney, and gastrointestinal tract sense NaCl including key cell types, the role of NaCl versus osmolality, and the underlying molecular and electrochemical mechanisms.

Indexed as

HypertensionSodium Chloride, DietaryBlood PressureBrainHumansKidneySodium ChlorideSodium ChlorideSodium Chloride, Dietaryangiotensin IIcardiovascular diseasesNaClrenalsodium

Identifiers

PMID37671571
PMCPMC10915107
OpenAlexW4386467569

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.