Evidence map›Paper›PMID 37671072›Full record

ArticleClinical interventions in aging2023

Treating Leaky Syndrome in the Over 65s: Progress and Challenges.

Shalini Jain, Francesco Marotta, Leila Haghshenas, Hariom Yadav

Abstract read
In one paragraph

Article in Clinical interventions in aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shalini JainDepartment of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA.
Francesco MarottaReGenera R&D International for Aging Intervention, Milano, Italy.
Leila HaghshenasDepartment of Clinical Bioinformatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4883-5977
Hariom YadavDepartment of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA.

Funding

Saliva based protein markers for predicting the risk of cognitive decline and dementia in older adults.R21AG082164 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI JAIN, SHALINI · 2023 to 2024
$412k
NIA NIH HHS R21 AG082164
6 · The paper itself

Abstract

As we age, our organ functions gradually decline. Circulating factors in the blood and the integrity of organ barriers can become dysfunctional, resulting in a condition known as leaky syndrome. This condition involves the unregulated exchange or leakage of components between organs. However, the triggers of leaky syndrome, as well as its role in aging-related disorders and illnesses, remain largely unknown. In this editorial, we discuss potential mechanisms that originate from the gut and resident microbes (microbiome) to contribute in leaky syndrome. Furthermore, we explore how the food we consume can impact the development of leaky syndrome, potentially influencing the biology of aging and challenges to diagnose the leaky gut condition accurately and clinically.

Indexed as

AgingHumansSyndromebarriergutinflammationleakymicrobiomesyndrome

Identifiers

PMID37671072
PMCPMC10476862

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.