Evidence map›Paper›PMID 37670807›Full record

ArticleImmune network2023

SARS-CoV-2 mRNA Vaccine Elicits Sustained T Cell Responses Against the Omicron Variant in Adolescents.

Sujin Choi, Sang-Hoon Kim, Mi Seon Han, Yoonsun Yoon, Yun-Kyung Kim, Hye-Kyung Cho, Ki Wook Yun, Seung Ha Song, Bin Ahn, Ye Kyung Kim and 12 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immune network, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 1 country.

Sujin ChoiDepartment of Pediatrics, Seoul National University Bundang Hospital, Seongnam 13620, Korea.ORCID https://orcid.org/0000-0001-5476-7029
Sang-Hoon KimThe Center for Viral Immunology, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon 34126, Korea.ORCID https://orcid.org/0000-0001-8200-191X
Mi Seon HanDepartment of Pediatrics, Seoul National University College of Medicine, Seoul 03080, Korea.ORCID https://orcid.org/0000-0002-3896-1400
Yoonsun YoonDepartment of Pediatrics, Korea University Guro Hospital, Seoul 08308, Korea.ORCID https://orcid.org/0000-0003-0187-3922
Yun-Kyung KimDepartment of Pediatrics, Korea University College of Medicine, Seoul 02841, Korea.ORCID https://orcid.org/0000-0003-4396-8671
Hye-Kyung ChoDepartment of Pediatrics, Gil Medical Center, Gachon University College of Medicine, Incheon 21565, Korea.ORCID https://orcid.org/0000-0003-0990-1350
Ki Wook YunDepartment of Pediatrics, Seoul National University College of Medicine, Seoul 03080, Korea.ORCID https://orcid.org/0000-0002-0798-6779
Seung Ha SongDepartment of Pediatrics, Seoul National University College of Medicine, Seoul 03080, Korea.ORCID https://orcid.org/0000-0002-3453-7645
Bin AhnDepartment of Pediatrics, Seoul National University College of Medicine, Seoul 03080, Korea.ORCID https://orcid.org/0000-0002-3806-4275
Ye Kyung KimDepartment of Pediatrics, Seoul National University College of Medicine, Seoul 03080, Korea.ORCID https://orcid.org/0000-0001-7145-8738
Sung Hwan ChoiDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul 03080, Korea.
Young June ChoeDepartment of Pediatrics, Korea University Anam Hospital, Seoul 02841, Korea.ORCID https://orcid.org/0000-0003-2733-0715
Heeji LimDivision of Vaccine Development Coordination, Center for Vaccine Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea.ORCID https://orcid.org/0000-0003-3546-9477
Eun Bee ChoiDivision of Vaccine Development Coordination, Center for Vaccine Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea.ORCID https://orcid.org/0000-0003-1309-2293
Kwangwook KimDivision of Vaccine Development Coordination, Center for Vaccine Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea.ORCID https://orcid.org/0000-0002-7200-871X
Seokhwan HyeonDivision of Vaccine Development Coordination, Center for Vaccine Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea.ORCID https://orcid.org/0000-0001-7909-326X
Hye Jung LimDivision of Vaccine Development Coordination, Center for Vaccine Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea.ORCID https://orcid.org/0000-0002-8296-9290
Byung-Chul KimDivision of Vaccine Development Coordination, Center for Vaccine Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea.ORCID https://orcid.org/0000-0002-9606-5153
Yoo-Kyoung LeeDivision of Vaccine Development Coordination, Center for Vaccine Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea.ORCID https://orcid.org/0000-0002-5639-8754
Eun Hwa ChoiDepartment of Pediatrics, Seoul National University College of Medicine, Seoul 03080, Korea.ORCID https://orcid.org/0000-0002-5857-0749
Eui-Cheol ShinThe Center for Viral Immunology, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon 34126, Korea.ORCID https://orcid.org/0000-0002-6308-9503
Hyunju LeeDepartment of Pediatrics, Seoul National University Bundang Hospital, Seongnam 13620, Korea.ORCID https://orcid.org/0000-0003-1174-4024
Seoul National University · KRKorea Disease Control and Prevention Agency · KRKorea University Medical Center · KRGachon University Gil Medical Center · KRInstitute for Basic Science · KRKorea Advanced Institute of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been acknowledged as an effective mean of preventing infection and hospitalization. However, the emergence of highly transmissible SARS-CoV-2 variants of concern (VOCs) has led to substantial increase in infections among children and adolescents. Vaccine-induced immunity and longevity have not been well defined in this population. Therefore, we aimed to analyze humoral and cellular immune responses against ancestral and SARS-CoV-2 variants after two shots of the BNT162b2 vaccine in healthy adolescents. Although vaccination induced a robust increase of spike-specific binding Abs and neutralizing Abs against the ancestral and SARS-CoV-2 variants, the neutralizing activity against the Omicron variant was significantly low. On the contrary, vaccine-induced memory CD4

Indexed as

AdolescentCOVID-19 vaccinesSARS-CoV-2SARS-CoV-2 variants

Identifiers

PMID37670807
PMCPMC10475828
OpenAlexW4386297735

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.