Evidence map›Paper›PMID 37670783›Full record

ArticleiScience2023

BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine.

Dilhan J Perera, Pilar Domenech, George Giorgi Babuadze, Maedeh Naghibosadat, Fernando Alvarez, Cal Koger-Pease, Lydia Labrie, Matthew Stuible, Yves Durocher, Ciriaco A Piccirillo and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Dilhan J PereraDivision of Experimental Medicine, McGill University, Montréal, QC, Canada.
Pilar DomenechInfectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada.
George Giorgi BabuadzeDepartment of Biological Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
Maedeh NaghibosadatDepartment of Biological Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
Fernando AlvarezInfectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada.
Cal Koger-PeaseDivision of Experimental Medicine, McGill University, Montréal, QC, Canada.
Lydia LabrieInfectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada.
Matthew StuibleDepartment of Production Platforms & Analytics, Human Health Therapeutics Research Center, National Research Council Canada, Montréal, QC, Canada.
Yves DurocherDepartment of Production Platforms & Analytics, Human Health Therapeutics Research Center, National Research Council Canada, Montréal, QC, Canada.
Ciriaco A PiccirilloDivision of Experimental Medicine, McGill University, Montréal, QC, Canada.
André LamettiDepartment of Pathology, McGill University, Montréal, QC, Canada.
Pierre Olivier FisetDepartment of Pathology, McGill University, Montréal, QC, Canada.
Seyyed Mehdy ElahiDepartment of Production Platforms & Analytics, Human Health Therapeutics Research Center, National Research Council Canada, Montréal, QC, Canada.
Gary P KobingerDépartement de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, QC, Canada.
Rénald GilbertDepartment of Production Platforms & Analytics, Human Health Therapeutics Research Center, National Research Council Canada, Montréal, QC, Canada.
Martin OlivierDivision of Experimental Medicine, McGill University, Montréal, QC, Canada.
Robert KozakDepartment of Biological Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
Michael B ReedInfectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada.
Momar NdaoDivision of Experimental Medicine, McGill University, Montréal, QC, Canada.
McGill University Health Centre · CANational Research Council Canada · CASunnybrook Health Science Centre · CAMcGill University · CAUniversité Laval · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent publications have explored intranasal (i.n.) adenovirus-based (Ad) vaccines as an effective strategy for SARS-CoV-2 in pre-clinical models. However, the effects of prior immunizations and infections have yet to be considered. Here, we investigate the immunomodulatory effects of

Indexed as

Biological sciencesImmune responseImmunologyMicrobiology

Identifiers

PMID37670783
PMCPMC10475483
OpenAlexW4385755593

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.