Evidence map›Paper›PMID 37670670›Full record

Observational studyJournal of intensive care medicine2024

Endothelial Glycocalyx Degradation Patterns in Sepsis-Associated Pediatric Acute Respiratory Distress Syndrome: A Single Center Retrospective Observational Study.

Colin J Sallee, Joseph A Hippensteel, Kristen R Miller, Kaori Oshima, Andrew T Pham, Robert P Richter, John Belperio, Yamila L Sierra, Andreas Schwingshackl, Peter M Mourani and 3 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of intensive care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Syndecan-1 as a Biomarker for Fluid Overload After High-Risk Pediatric Cardiac Surgery: A Pilot Study.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025
    Observational
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Colin J SalleeDepartment of Pediatrics, Division of Pediatric Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles and Mattel Children's Hospital, Los Angeles, CA, USA.ORCID 0000-0002-2834-2657
Joseph A HippensteelDepartment of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Kristen R MillerDepartment of Pediatrics, Section of Pediatric Critical Care, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Kaori OshimaDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.
Andrew T PhamDepartment of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Robert P RichterDepartment of Pediatrics, Division of Pediatric Critical Care Medicine, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
John BelperioDepartment of Medicine, Division of Pulmonary Critical Care and Sleep Medicine, David Geffen School of Medicine at University of California Los Angeles and Ronald Reagan Medical Center, Los Angeles, CA, USA.
Yamila L SierraDepartment of Pediatrics, Section of Pediatric Critical Care, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Andreas SchwingshacklDepartment of Pediatrics, Division of Pediatric Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles and Mattel Children's Hospital, Los Angeles, CA, USA.
Peter M MouraniDepartment of Pediatrics, Division of Pediatric Critical Care Medicine, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, AR, USA.
Eric P SchmidtDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.
Anil SapruDepartment of Pediatrics, Division of Pediatric Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles and Mattel Children's Hospital, Los Angeles, CA, USA.
Aline B MadduxDepartment of Pediatrics, Section of Pediatric Critical Care, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
University of California, Los Angeles · USChildren's Hospital Colorado · USHarvard University · USUniversity of Colorado Anschutz Medical Campus · USArkansas Children's Hospital · USUniversity of Alabama at Birmingham · US

Funding

hHv1 channels in neutrophils and the innate immune inflammatory responseR01HL159711 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDSTEIN, STEVE A N, ZHAO, RUIMING · 2022 to 2025
$2.4M
The Role of TREK-1 potassium channels in ARDSR01HL175464 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Andreas Schwingshackl · 2024 to 2026
$2.3M
The Impact of Fluid Resuscitation on Glycocalyx Degradation in Septic ShockR01HL149422 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCHMIDT, ERIC PETER, SHAPIRO, NATHAN I · 2019 to 2022
$1.7M
Mechanisms driving endothelial angiopoietin-2 expression and vascular dysfunction during pediatric sepsisK08GM144788 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RICHTER, ROBERT P · 2021 to 2025
$930k
Lung-Brain Axis as a Mediator of DeliriumK08HL159353 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI HIPPENSTEEL, JOSEPH ALAN · 2021 to 2025
$809k
Functional Outcomes after Prolonged Mechanical Ventilation in ChildrenK23HD096018 · NICHD · UNIVERSITY OF COLORADO DENVER · PI MADDUX, ALINE BERNARD · 2019 to 2023
$807k
Endothelial Glycocalyx Degradation during Sepsis in AgingR03AG074056 · NIA · UNIVERSITY OF COLORADO DENVER · PI HIPPENSTEEL, JOSEPH ALAN · 2021 to 2022
$311k
NHLBI NIH HHS K08 HL159353NHLBI NIH HHS R01 HL149422NHLBI NIH HHS R01 HL159711NHLBI NIH HHS R01 HL175464NIA NIH HHS R03 AG074056NICHD NIH HHS K23 HD096018NIGMS NIH HHS K08 GM144788
6 · The paper itself

Abstract

backgroundSepsis-associated destruction of the pulmonary microvascular endothelial glycocalyx (EGCX) creates a vulnerable endothelial surface, contributing to the development of acute respiratory distress syndrome (ARDS). Constituents of the EGCX shed into circulation, glycosaminoglycans and proteoglycans, may serve as biomarkers of endothelial dysfunction. We sought to define the patterns of plasma EGCX degradation products in children with sepsis-associated pediatric ARDS (PARDS), and test their association with clinical outcomes.

methodsWe retrospectively analyzed a prospective cohort (2018-2020) of children (≥1 month to <18 years of age) receiving invasive mechanical ventilation for acute respiratory failure for ≥72 h. Children with and without sepsis-associated PARDS were selected from the parent cohort and compared. Blood was collected at time of enrollment. Plasma glycosaminoglycan disaccharide class (heparan sulfate, chondroitin sulfate, and hyaluronan) and sulfation subtypes (heparan sulfate and chondroitin sulfate) were quantified using liquid chromatography tandem mass spectrometry. Plasma proteoglycans (syndecan-1) were measured through an immunoassay.

resultsAmong the 39 mechanically ventilated children (29 with and 10 without sepsis-associated PARDS), sepsis-associated PARDS patients demonstrated higher levels of heparan sulfate (median 639 ng/mL [interquartile range, IQR 421-902] vs 311 [IQR 228-461]) and syndecan-1 (median 146 ng/mL [IQR 32-315] vs 8 [IQR 8-50]), both

conclusionsChildren with sepsis-associated PARDS exhibited higher plasma levels of heparan sulfate disaccharides and syndecan-1, suggesting that EGCX degradation biomarkers may provide insights into endothelial dysfunction and PARDS pathobiology.

Indexed as

Respiratory Distress SyndromeSepsisBiomarkersChildChondroitin SulfatesDisaccharidesGlycocalyxHeparan SulfateHumansProspective StudiesProteoglycansRetrospective StudiesSyndecan-1BiomarkersChondroitin SulfatesDisaccharidesHeparan SulfateProteoglycansSyndecan-1acute respiratory distress syndromeglycocalyxglycosaminoglycanmechanical ventilationpediatric intensive carepediatricsproteoglycansepsis

Identifiers

PMID37670670
PMCPMC10845819
OpenAlexW4386466887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.